Literature DB >> 9125373

Use of gene targeting for compromising energy homeostasis in neuro-muscular tissues: the role of sarcomeric mitochondrial creatine kinase.

K Steeghs1, A Heerschap, A de Haan, W Ruitenbeek, F Oerlemans, J van Deursen, B Perryman, D Pette, M Brückwilder, J Koudijs, P Jap, B Wieringa.   

Abstract

We have introduced a single knock-out mutation in the mitochondrial creatine kinase gene (ScCKmit) in the mouse germ line via targeted mutagenesis in mouse embryonic stem (ES) cells. Surprisingly, ScCKmit -/- muscles, unlike muscles of mice with a deficiency of cytosolic M-type creatine kinase (M-CK -/-; Van Deursen et al. (1993) Cell 74, 621-631), display no altered morphology, performance or oxidative phosphorylation capacity. Also, the levels of high energy phosphate metabolites were essentially unaltered in ScCKmit mutants. Our results challenge some of the present concepts about the strict coupling between CKmit function and aerobic respiration.

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Year:  1997        PMID： 9125373     DOI： 10.1016/s0165-0270(96)00124-0

Source DB:  PubMed          Journal:  J Neurosci Methods        ISSN： 0165-0270            Impact factor:   2.390


  10 in total

1.  An MR-compatible device for the in situ assessment of isometric contractile performance of mouse hind-limb ankle flexors.

Authors:  Maarten R Drost; Anneriet M Heemskerk; Gustav J Strijkers; Erwin C Dekkers; Gerrit van Kranenburg; Klaas Nicolay
Journal:  Pflugers Arch       Date:  2003-10-07       Impact factor: 3.657

2.  Cytoarchitectural and metabolic adaptations in muscles with mitochondrial and cytosolic creatine kinase deficiencies.

Authors:  K Steeghs; F Oerlemans; A de Haan; A Heerschap; L Verdoodt; M de Bie; W Ruitenbeek; A Benders; C Jost; J van Deursen; P Tullson; R Terjung; P Jap; W Jacob; D Pette; B Wieringa
Journal:  Mol Cell Biochem       Date:  1998-07       Impact factor: 3.396

Review 3.  Creatine metabolism: energy homeostasis, immunity and cancer biology.

Authors:  Lawrence Kazak; Paul Cohen
Journal:  Nat Rev Endocrinol       Date:  2020-06-03       Impact factor: 43.330

4.  Regulation of sodium-calcium exchanger activity by creatine kinase under energy-compromised conditions.

Authors:  Ya-Chi Yang; Ming-Ji Fann; Wen-Hsin Chang; Long-Hao Tai; Jhih-Hang Jiang; Lung-Sen Kao
Journal:  J Biol Chem       Date:  2010-06-24       Impact factor: 5.157

5.  Mitochondrial creatine kinase functional development in post-natal rat skeletal muscle. A combined polarographic/31P NMR study.

Authors:  F Kernec; L Nadal; C Rocher; P Mateo; J de Certaines; E Le Rumeur
Journal:  Mol Cell Biochem       Date:  1999-04       Impact factor: 3.396

6.  Increased resistance to fatigue in creatine kinase deficient muscle is not due to improved contractile economy.

Authors:  Frank ter Veld; Klaas Nicolay; Jeroen A L Jeneson
Journal:  Pflugers Arch       Date:  2006-03-11       Impact factor: 3.657

7.  Disturbed energy metabolism and muscular dystrophy caused by pure creatine deficiency are reversible by creatine intake.

Authors:  C I Nabuurs; C U Choe; A Veltien; H E Kan; L J C van Loon; R J T Rodenburg; J Matschke; B Wieringa; G J Kemp; D Isbrandt; A Heerschap
Journal:  J Physiol       Date:  2012-11-05       Impact factor: 5.182

Review 8.  The Pitfalls of in vivo Cardiac Physiology in Genetically Modified Mice - Lessons Learnt the Hard Way in the Creatine Kinase System.

Authors:  Craig A Lygate
Journal:  Front Physiol       Date:  2021-05-14       Impact factor: 4.566

Review 9.  Role of creatine kinase isoenzymes on muscular and cardiorespiratory endurance: genetic and molecular evidence.

Authors:  M Echegaray; M A Rivera
Journal:  Sports Med       Date:  2001       Impact factor: 11.928

Review 10.  Energy metabolism design of the striated muscle cell.

Authors:  Brian Glancy; Robert S Balaban
Journal:  Physiol Rev       Date:  2021-03-18       Impact factor: 46.500
  10 in total

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