Literature DB >> 9119377

The human erythroid-specific transcription factor EKLF localizes to chromosome 19p13.12-p13.13.

J H van Ree1, M A Roskrow, A M Becher, R McNall, V A Valentine, S M Jane, J M Cunningham.   

Abstract

Erythroid Krüppel-like factor (EKLF) is a trans-acting factor that binds specifically to the beta-globin promoter CACCC box. EKLF is essential for adult erythroid development in mice. We have cloned and sequenced a cDNA encoding the human homologue of this gene, which shares 69% identity with the mEKLF protein. The expression of hEKLF is restricted to fetal liver and adult bone marrow. The genomic locus of hEKLF was mapped to chromosomal band 19p13.12-p13.13, using fluorescence in situ hybridization.

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Year:  1997        PMID： 9119377     DOI： 10.1006/geno.1996.4472

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  5 in total

Review 1.  A tale of three fingers: the family of mammalian Sp/XKLF transcription factors.

Authors:  S Philipsen; G Suske
Journal:  Nucleic Acids Res       Date:  1999-08-01       Impact factor: 16.971

2.  Distinct domains of erythroid Krüppel-like factor modulate chromatin remodeling and transactivation at the endogenous beta-globin gene promoter.

Authors:  R Clark Brown; Scott Pattison; Janine van Ree; Elise Coghill; Andrew Perkins; Stephen M Jane; John M Cunningham
Journal:  Mol Cell Biol       Date:  2002-01       Impact factor: 4.272

3.  Erythroid Krüppel-like transcription factor (Eklf) maps to a region of mouse chromosome 8 syntenic with human chromosome 19.

Authors:  N A Jenkins; D J Gilbert; N G Copeland; E Gruzglin; J J Bieker
Journal:  Mamm Genome       Date:  1998-02       Impact factor: 2.957

4.  A global role for EKLF in definitive and primitive erythropoiesis.

Authors:  Denise Hodge; Elise Coghill; Janelle Keys; Tina Maguire; Belinda Hartmann; Alasdair McDowall; Mitchell Weiss; Sean Grimmond; Andrew Perkins
Journal:  Blood       Date:  2005-12-27       Impact factor: 22.113

5.  Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis.

Authors:  V Ratziu; A Lalazar; L Wong; Q Dang; C Collins; E Shaulian; S Jensen; S L Friedman
Journal:  Proc Natl Acad Sci U S A       Date:  1998-08-04       Impact factor: 11.205
  5 in total

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