Literature DB >> 9118876

8-Hydroxydeoxyguanosine in human leukocyte DNA and daily health practice factors: effects of individual alcohol sensitivity.

M Nakajima1, T Takeuchi, T Takeshita, K Morimoto.   

Abstract

A typical oxidative DNA damage, 8-hydroxydeoxyguanosine (8-OHdG), was evaluated in human polymorphonuclear leukocytes (PMN) and mononuclear leukocytes (MN) by an anaerobic determination method. The mean 8-OHdG values were the lowest level ever reported [PMN, 3.07 +/- 1.45; MN, 2.37 +/- 1.21 8-OHdG/10(6) deoxyguanosine molecules (dG); n = 92]. According to a self-administered questionnaire to 92 healthy male workers, the relationship was investigated between 8-OHdG in leukocytes and daily health practice factors, that is, the frequency of physical exercise, smoking status, alcohol drinking, nutritional balance, and the degree of mental stress. A significant difference was observed only in alcohol drinking in subjects classified by aldehyde-dehydrogenase 2 isozyme (ALDH2) genotype. Habitual alcohol intake appeared to increase 8-OHdG in PMN from ALDH2-deficient subjects. Neither age, body mass index, nor any other factors examined showed any significant correlation with the 8-OHdG levels in leukocytes.

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Year:  1996        PMID： 9118876      PMCID： PMC1469550          DOI： 10.1289/ehp.961041336

Source DB:  PubMed          Journal:  Environ Health Perspect        ISSN： 0091-6765            Impact factor:   9.031


  24 in total

Review 1.  The role of 8-hydroxyguanine in carcinogenesis.

Authors:  R A Floyd
Journal:  Carcinogenesis       Date:  1990-09       Impact factor: 4.944

2.  Increase of a type of oxidative DNA damage, 8-hydroxyguanine, and its repair activity in human leukocytes by cigarette smoking.

Authors:  S Asami; T Hirano; R Yamaguchi; Y Tomioka; H Itoh; H Kasai
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3.  Aldehyde dehydrogenase deficiency as cause of facial flushing reaction to alcohol in Japanese.

Authors:  S Harada; D P Agarwal; H W Goedde
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4.  Determination of 8-hydroxydeoxyguanosine in human cells under oxygen-free conditions.

Authors:  M Nakajima; T Takeuchi; K Morimoto
Journal:  Carcinogenesis       Date:  1996-04       Impact factor: 4.944

5.  Characterization of the three genotypes of low Km aldehyde dehydrogenase in a Japanese population.

Authors:  T Takeshita; K Morimoto; X Mao; T Hashimoto; J Furuyama
Journal:  Hum Genet       Date:  1994-09       Impact factor: 4.132

6.  Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2.

Authors:  L C Hsu; K Tani; T Fujiyoshi; K Kurachi; A Yoshida
Journal:  Proc Natl Acad Sci U S A       Date:  1985-06       Impact factor: 11.205

7.  Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA.

Authors:  H Kasai; S Nishimura; Y Kurokawa; Y Hayashi
Journal:  Carcinogenesis       Date:  1987-12       Impact factor: 4.944

8.  Evaluation of 8-hydroxydeoxyguanosine, a typical oxidative DNA damage, in human leukocytes.

Authors:  T Takeuchi; M Nakajima; Y Ohta; K Mure; T Takeshita; K Morimoto
Journal:  Carcinogenesis       Date:  1994-08       Impact factor: 4.944

9.  Establishment of a human system that generates O2- and induces 8-hydroxydeoxyguanosine, typical of oxidative DNA damage, by a tumor promotor.

Authors:  T Takeuchi; M Nakajima; K Morimoto
Journal:  Cancer Res       Date:  1994-11-15       Impact factor: 12.701

10.  Formation of 8-hydroxydeoxyguanosine, hydroxyl free radical adduct of DNA in granulocytes exposed to the tumor promoter, tetradecanoylphorbolacetate.

Authors:  R A Floyd; J J Watson; J Harris; M West; P K Wong
Journal:  Biochem Biophys Res Commun       Date:  1986-06-13       Impact factor: 3.575
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3.  Leukocyte 8-hydroxydeoxyguanosine and aromatic DNA adduct in coke-oven workers with polycyclic aromatic hydrocarbon exposure.

Authors:  J Zhang; M Ichiba; T Hanaoka; G Pan; Y Yamano; K Hara; K Takahashi; K Tomokuni
Journal:  Int Arch Occup Environ Health       Date:  2003-07-03       Impact factor: 3.015

4.  Clustered DNA damage induced by gamma radiation in human fibroblasts (HF19), hamster (V79-4) cells and plasmid DNA is revealed as Fpg and Nth sensitive sites.

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Journal:  Nucleic Acids Res       Date:  2002-08-01       Impact factor: 16.971

Review 5.  Artifacts associated with the measurement of oxidized DNA bases.

Authors:  J Cadet; T Douki; J L Ravanat
Journal:  Environ Health Perspect       Date:  1997-10       Impact factor: 9.031

6.  Exposure to indoor background radiation and urinary concentrations of 8-hydroxydeoxyguanosine, a marker of oxidative DNA damage.

Authors:  A Sperati; D D Abeni; C Tagesson; F Forastiere; M Miceli; O Axelson
Journal:  Environ Health Perspect       Date:  1999-03       Impact factor: 9.031

7.  Psychosocial factors as a potential trigger of oxidative DNA damage in human leukocytes.

Authors:  M Irie; S Asami; S Nagata; M Ikeda; M Miyata; H Kasai
Journal:  Jpn J Cancer Res       Date:  2001-03

8.  Lack of direct involvement of 8-hydroxy-2'-deoxyguanosine in hypoxanthine-guanine phosphoribosyltransferase mutagenesis in V79 cells treated with N,N'-bis(2-hydroxyperoxy-2-methoxyethyl)-1,4,5,8-naphthalenetetracarboxylic-diimide (NP-III) or riboflavin.

Authors:  Madoka Nakajima; Toru Takeuchi; Keiki Ogino; Kanehisa Morimoto
Journal:  Jpn J Cancer Res       Date:  2002-03

9.  Unique signatures of natural background radiation on human Y chromosomes from Kerala, India.

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Journal:  PLoS One       Date:  2009-02-26       Impact factor: 3.240

10.  Is the oxidative DNA damage level of human lymphocyte correlated with the antioxidant capacity of serum or the base excision repair activity of lymphocyte?

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Journal:  Oxid Med Cell Longev       Date:  2013-11-14       Impact factor: 6.543
  10 in total

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