Literature DB >> 3677321

Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA.

H Kasai1, S Nishimura, Y Kurokawa, Y Hayashi.   

Abstract

Following oral administration of a renal carcinogen, potassium bromate (KBrO3), to the rat, a significant increase of 8-hydroxydeoxyguanosine (8-OH-dG) in kidney DNA was observed. In the liver, a non-target tissue, the increase in 8-OH-dG was not significant. The non carcinogenic oxidants, NaCIO and NaCIO2, had no effect on 8-OH-dG formation in kidney DNA. These results suggest that formation of 8-OH-dG in tissue DNA is closely related to KBrO3 carcinogenesis.

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Year:  1987        PMID： 3677321     DOI： 10.1093/carcin/8.12.1959

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  53 in total

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Review 2.  Formation and repair of oxidatively generated damage in cellular DNA.

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3.  Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

Authors:  C Richter; J W Park; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1988-09       Impact factor: 11.205

4.  Potent and Selective Inhibitors of 8-Oxoguanine DNA Glycosylase.

Authors:  Yu-Ki Tahara; Douglas Auld; Debin Ji; Andrew A Beharry; Anna M Kietrys; David L Wilson; Marta Jimenez; Daniel King; Zachary Nguyen; Eric T Kool
Journal:  J Am Chem Soc       Date:  2018-02-05       Impact factor: 15.419

5.  Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma.

Authors:  T M Hagen; S Huang; J Curnutte; P Fowler; V Martinez; C M Wehr; B N Ames; F V Chisari
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-20       Impact factor: 11.205

6.  Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.

Authors:  C G Fraga; M K Shigenaga; J W Park; P Degan; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1990-06       Impact factor: 11.205

7.  Leukocyte 8-hydroxydeoxyguanosine and aromatic DNA adduct in coke-oven workers with polycyclic aromatic hydrocarbon exposure.

Authors:  J Zhang; M Ichiba; T Hanaoka; G Pan; Y Yamano; K Hara; K Takahashi; K Tomokuni
Journal:  Int Arch Occup Environ Health       Date:  2003-07-03       Impact factor: 3.015

8.  A possible role for cell proliferation in potassium bromate (KBrO3) carcinogenesis.

Authors:  T Umemura; K Sai; A Takagi; R Hasegawa; Y Kurokawa
Journal:  J Cancer Res Clin Oncol       Date:  1993       Impact factor: 4.553

9.  Quantitative analysis of 8-hydroxyguanine in peripheral blood cells: an application for asbestosis patients.

Authors:  T Hanaoka; S Tsugane; Y Yamano; T Takahashi; H Kasai; Y Natori; S Watanabe
Journal:  Int Arch Occup Environ Health       Date:  1993       Impact factor: 3.015

10.  7-Methylguanine adducts in DNA are normally present at high levels and increase on aging: analysis by HPLC with electrochemical detection.

Authors:  J W Park; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205
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