STUDY OBJECTIVE: This study aimed to determine the differences between ciliary beat frequencies of respiratory ciliated cells from peripheral bronchioles and from proximal bronchi in humans. DESIGN: Measurements were made from resected lungs. Ciliated cells were harvested by brushing the mucosa of each site immediately after surgery. Brushings with a cytology brush were performed on normal areas of the resected cartilaginous bronchus for proximal samplings and through a peripheral bronchiole close to the visceral pleura for peripheral samplings. For each site, at least 12 different measurements were made at 22 degrees C using an image analysis system. RESULTS: A highly significant difference between proximal bronchi (mean, 7.1 Hz; SD, 1.29) and peripheral bronchioles (mean, 4.6 Hz; SD, 1.39) (p < 0.0001) was found. CONCLUSION: Thus, cilia from peripheral bronchioles beat at a 35% lower beat frequency than cilia from proximal bronchi.
STUDY OBJECTIVE: This study aimed to determine the differences between ciliary beat frequencies of respiratory ciliated cells from peripheral bronchioles and from proximal bronchi in humans. DESIGN: Measurements were made from resected lungs. Ciliated cells were harvested by brushing the mucosa of each site immediately after surgery. Brushings with a cytology brush were performed on normal areas of the resected cartilaginous bronchus for proximal samplings and through a peripheral bronchiole close to the visceral pleura for peripheral samplings. For each site, at least 12 different measurements were made at 22 degrees C using an image analysis system. RESULTS: A highly significant difference between proximal bronchi (mean, 7.1 Hz; SD, 1.29) and peripheral bronchioles (mean, 4.6 Hz; SD, 1.39) (p < 0.0001) was found. CONCLUSION: Thus, cilia from peripheral bronchioles beat at a 35% lower beat frequency than cilia from proximal bronchi.
Authors: Carolin A Boecking; Peter Walentek; Lorna T Zlock; Dingyuan I Sun; Paul J Wolters; Hiroaki Ishikawa; Byung-Ju Jin; Peter M Haggie; Wallace F Marshall; Alan S Verkman; Walter E Finkbeiner Journal: Am J Physiol Lung Cell Mol Physiol Date: 2022-01-26 Impact factor: 5.464
Authors: Berglind Eva Benediktsdóttir; Ari Jón Arason; Skarphédinn Halldórsson; Thórarinn Gudjónsson; Már Másson; Olafur Baldursson Journal: Pharm Res Date: 2012-11-08 Impact factor: 4.200
Authors: Nina Lodes; Katharina Seidensticker; Alexander Perniss; Sarah Nietzer; Heike Oberwinkler; Tobias May; Thorsten Walles; Helge Hebestreit; Stephan Hackenberg; Maria Steinke Journal: Tissue Eng Part A Date: 2019-12-27 Impact factor: 3.845