Literature DB >> 9118455

Synthesis and antitumor activity of fused quinoline derivatives. IV. Novel 11-aminoindolo[3,2-b]quinolines.

Y Takeuchi1, T Oda, M R Chang, Y Okamoto, J Ono, Y Oda, K Harada, K Hashigaki, M Yamato.   

Abstract

Indolo[3,2-b]quinoline derivatives (1) having various amine moieties were prepared and their antitumor activities against P388 leukemia in mice were evaluated, for the purpose of gaining an insight into the role of the amine moiety in the antitumor activity and searching for an effective amine moiety. Introduction of a methylene group between the phenyl group and amino or methanesulfonamido group resulted in decrease or loss of activity.

Entities:  

Mesh：

Substances：

Year:  1997        PMID： 9118455     DOI： 10.1248/cpb.45.406

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  6 in total

1.  Rh(II)2-catalyzed synthesis of α-, β-, or δ-carbolines from aryl azides.

Authors:  Ashley L Pumphrey; Huijun Dong; Tom G Driver
Journal:  Angew Chem Int Ed Engl       Date:  2012-04-26       Impact factor: 15.336

2.  Effect of quinolinyl acrylate derivatives on prostate cancer in vitro and in vivo.

Authors:  Juan R Rodrigues; Jaime Charris; Rosa Ferrer; Neira Gamboa; Jorge Angel; Bianca Nitzsche; Michael Hoepfner; Michael Lein; Klaus Jung; Claudia Abramjuk
Journal:  Invest New Drugs       Date:  2011-07-12       Impact factor: 3.850

3.  Intercalative pyrimido[4',5':4,5]thieno(2,3-b)quinolines induce apoptosis in leukemic cells: a comparative study of methoxy and morpholino substitution.

Authors:  M S Shahabuddin; Mridula Nambiar; Gopal M Advirao; Sathees C Raghavan
Journal:  Invest New Drugs       Date:  2010-04-28       Impact factor: 3.850

4.  A novel structural derivative of natural alkaloid ellipticine, MDPSQ, induces necrosis in leukemic cells.

Authors:  M S Shahabuddin; Mridula Nambiar; Balaji T Moorthy; Prakruthi L Naik; Bibha Choudhary; Gopal M Advirao; Sathees C Raghavan
Journal:  Invest New Drugs       Date:  2010-01-13       Impact factor: 3.850

5.  The discovery of a novel series of potential ERRα inverse agonists based on p-nitrobenzenesulfonamide template for triple-negative breast cancer in vivo.

Authors:  Zhipei Gao; Tianxiao Wang; Rui Li; Yongli Du; Han Lv; Liudi Zhang; Haifei Chen; Xiaojin Shi; Qunyi Li; Jingkang Shen
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.051

6.  Synthesis of novel indolo[3,2-c]isoquinoline derivatives bearing pyrimidine, piperazine rings and their biological evaluation and docking studies against COVID-19 virus main protease.

Authors:  Vaijinath A Verma; Anand R Saundane; Rajkumar S Meti; Dushyanth R Vennapu
Journal:  J Mol Struct       Date:  2020-12-27       Impact factor: 3.196
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.