Literature DB >> 20069337

A novel structural derivative of natural alkaloid ellipticine, MDPSQ, induces necrosis in leukemic cells.

M S Shahabuddin1, Mridula Nambiar, Balaji T Moorthy, Prakruthi L Naik, Bibha Choudhary, Gopal M Advirao, Sathees C Raghavan.   

Abstract

DNA intercalating molecules are promising chemotherapeutic agents. In the present study, a novel DNA intercalating compound of pyrimido[4',5':4,5]selenolo(2,3-b)quinoline series having 8-methyl-4-(3 diethylaminopropylamino) side chain is studied for its chemotherapeutic properties. Our results showed that 8-methyl-4-(3 diethylaminopropylamino) pyrimido [4',5':4,5] selenolo(2,3-b)quinoline (MDPSQ) induces cytotoxicity in a time- and concentration-dependent manner on leukemic cell lines. Both cell cycle analysis and tritiated thymidine assays revealed that MDPSQ affects DNA replication. Treatment with MDPSQ resulted in both elevated levels of DNA strand breaks and repair proteins, further indicating its cytotoxic effects. Besides, Annexin V/PI staining revealed that MDPSQ induces cell death by triggering necrosis rather than apoptosis.

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Year:  2010        PMID： 20069337     DOI： 10.1007/s10637-009-9379-5

Source DB:  PubMed          Journal:  Invest New Drugs        ISSN： 0167-6997            Impact factor:   3.850


  36 in total

Review 1.  Chromosome translocations: dangerous liaisons revisited.

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Journal:  Nat Rev Cancer       Date:  2001-12       Impact factor: 60.716

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Journal:  Proc Soc Exp Biol Med       Date:  1999-06

3.  F16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell.

Authors:  Valeria R Fantin; Philip Leder
Journal:  Cancer Res       Date:  2004-01-01       Impact factor: 12.701

4.  Preliminary trial of 9-hydroxy-2-methyl ellipticinium (NSC 264--137) in advanced human cancers.

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Journal:  Eur J Cancer       Date:  1978-02       Impact factor: 9.162

5.  Synthesis and antitumor activity of fused quinoline derivatives. IV. Novel 11-aminoindolo[3,2-b]quinolines.

Authors:  Y Takeuchi; T Oda; M R Chang; Y Okamoto; J Ono; Y Oda; K Harada; K Hashigaki; M Yamato
Journal:  Chem Pharm Bull (Tokyo)       Date:  1997-02       Impact factor: 1.645

6.  Covalent binding of the anticancer drug ellipticine to DNA in V79 cells transfected with human cytochrome P450 enzymes.

Authors:  Eva Frei; Christian A Bieler; Volker M Arlt; Manfred Wiessler; Marie Stiborová
Journal:  Biochem Pharmacol       Date:  2002-07-15       Impact factor: 5.858

Review 7.  Radiation-induced apoptosis: relevance to radiotherapy.

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Journal:  Int J Radiat Oncol Biol Phys       Date:  1995-11-01       Impact factor: 7.038

8.  Intercalating, cytotoxic, antitumour activity of 8-chloro and 4-morpholinopyrimido [4',5':4,5]thieno(2,3-b)quinolines.

Authors:  M S Shahabuddin; M Gopal; Sathees C Raghavan
Journal:  J Photochem Photobiol B       Date:  2008-09-13       Impact factor: 6.252

Review 9.  Chromosomal translocations in cancer.

Authors:  Mridula Nambiar; Vijayalakshmi Kari; Sathees C Raghavan
Journal:  Biochim Biophys Acta       Date:  2008-07-31

10.  Biological properties of 8-methoxypyrimido[4(1),5(1):4,5]thieno(2,3-b)quinoline-4(3H)-one, a new class of DNA intercalating drugs.

Authors:  M Gopal; M S Shahabuddin
Journal:  Indian J Med Res       Date:  2004-05       Impact factor: 2.375
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  10 in total

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2.  Intercalative pyrimido[4',5':4,5]thieno(2,3-b)quinolines induce apoptosis in leukemic cells: a comparative study of methoxy and morpholino substitution.

Authors:  M S Shahabuddin; Mridula Nambiar; Gopal M Advirao; Sathees C Raghavan
Journal:  Invest New Drugs       Date:  2010-04-28       Impact factor: 3.850

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7.  Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibits tumor progression in mice.

Authors:  Ranganatha R Somasagara; Mahesh Hegde; Kishore K Chiruvella; Anjaneyulu Musini; Bibha Choudhary; Sathees C Raghavan
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8.  Propyl-2-(8-(3,4-difluorobenzyl)-2',5'-dioxo-8-azaspiro[bicyclo[3.2.1] octane-3,4'-imidazolidine]-1'-yl) acetate induces apoptosis in human leukemia cells through mitochondrial pathway following cell cycle arrest.

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9.  Calpain: a molecule to induce AIF-mediated necroptosis in RGC-5 following elevated hydrostatic pressure.

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10.  Extract of Vernonia condensata, Inhibits Tumor Progression and Improves Survival of Tumor-allograft Bearing Mouse.

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  10 in total

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