Literature DB >> 9117556

Structural correlates of cognition in dementia: quantification and assessment of synapse change.

S T DeKosky1, S W Scheff, S D Styren.   

Abstract

Dementia results from a combination of structural and neurochemical pathologies. The most reliable index of cognition in both postmortem and biopsied AD brain is synapse loss.

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Year:  1996        PMID： 9117556     DOI： 10.1006/neur.1996.0056

Source DB:  PubMed          Journal:  Neurodegeneration        ISSN： 1055-8330


  137 in total

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3.  Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease.

Authors:  Eloise Hudry; Hai-Yan Wu; Michal Arbel-Ornath; Tadafumi Hashimoto; Roland Matsouaka; Zhanyun Fan; Tara L Spires-Jones; Rebecca A Betensky; Brian J Bacskai; Bradley T Hyman
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Review 4.  Multi-dimensional mass spectrometry-based shotgun lipidomics and the altered lipids at the mild cognitive impairment stage of Alzheimer's disease.

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5.  Detection of peri-synaptic amyloid-β pyroglutamate aggregates in early stages of Alzheimer's disease and in AβPP transgenic mice using a novel monoclonal antibody.

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6.  Spatial relationship between synapse loss and beta-amyloid deposition in Tg2576 mice.

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8.  Rubus coreanus Miquel inhibits acetylcholinesterase activity and prevents cognitive impairment in a mouse model of dementia.

Authors:  Cho Rong Kim; Soo Jung Choi; Seung Sang Oh; Yoon Kyung Kwon; Na Young Lee; Gwi Gun Park; Youn-Jung Kim; Ho Jin Heo; Woo Jin Jun; Cheung-Seog Park; Dong-Hoon Shin
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9.  Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy.

Authors:  Tara L Spires; Melanie Meyer-Luehmann; Edward A Stern; Pamela J McLean; Jesse Skoch; Paul T Nguyen; Brian J Bacskai; Bradley T Hyman
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Review 10.  Using Pittsburgh Compound B for in vivo PET imaging of fibrillar amyloid-beta.

Authors:  Ann D Cohen; Gil D Rabinovici; Chester A Mathis; William J Jagust; William E Klunk; Milos D Ikonomovic
Journal:  Adv Pharmacol       Date:  2012
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