Literature DB >> 24044488

Rubus coreanus Miquel inhibits acetylcholinesterase activity and prevents cognitive impairment in a mouse model of dementia.

Cho Rong Kim1, Soo Jung Choi, Seung Sang Oh, Yoon Kyung Kwon, Na Young Lee, Gwi Gun Park, Youn-Jung Kim, Ho Jin Heo, Woo Jin Jun, Cheung-Seog Park, Dong-Hoon Shin.   

Abstract

To find acetylcholinesterase (AChE) inhibitors for the prevention of neurological disorders, such as Alzheimer's disease, ethanol extracts of promising traditional edible Korean plants were tested. Among them, Rubus coreanus Miquel extract exhibited the most significant AChE inhibitory activity. The effect of R. coreanus extract on trimethyltin-induced memory impairment in mice was investigated using Y-maze and passive avoidance tests. Our results showed that administration of R. coreanus extract significantly improved alternation behavior and step-through latency. In addition, R. coreanus extract was sequentially fractionated, and the purified constituent was determined to be 3,4,5-trihydroxybenzoic acid.

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Year:  2013        PMID： 24044488      PMCID： PMC3778953          DOI： 10.1089/jmf.2012.2663

Source DB:  PubMed          Journal:  J Med Food        ISSN： 1096-620X            Impact factor:   2.786


  25 in total

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Authors:  Eng Shi Ong
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2004-12-05       Impact factor: 3.205

Review 2.  Health benefits of fruits and vegetables.

Authors:  Joanne L Slavin; Beate Lloyd
Journal:  Adv Nutr       Date:  2012-07-01       Impact factor: 8.701

3.  Treatment of Alzheimer disease.

Authors:  Bradford T Winslow; Mary K Onysko; Christian M Stob; Kathleen A Hazlewood
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4.  Hippocampal muscarinic receptor loss following trimethyl tin administration.

Authors:  C C Loullis; R L Dean; A S Lippa; D E Clody; J Coupet
Journal:  Pharmacol Biochem Behav       Date:  1985-01       Impact factor: 3.533

5.  Gallic acid, a histone acetyltransferase inhibitor, suppresses β-amyloid neurotoxicity by inhibiting microglial-mediated neuroinflammation.

Authors:  Mi-Jeong Kim; Ah-Reum Seong; Jung-Yoon Yoo; Cheng-Hao Jin; Yoo-Hyun Lee; Young Jun Kim; Jeongmin Lee; Woo Jin Jun; Ho-Geun Yoon
Journal:  Mol Nutr Food Res       Date:  2011-10-31       Impact factor: 5.914

6.  Fatigue-alleviating effect on mice of an ethanolic extract from Rubus coreanus.

Authors:  Somi Lee; Yanghee You; Ho-Geun Yoon; Kyungmi Kim; Jeongjin Park; Sunoh Kim; Jin-Nyoung Ho; Jeongmin Lee; Sangin Shim; Woojin Jun
Journal:  Biosci Biotechnol Biochem       Date:  2011-02-07       Impact factor: 2.043

Review 7.  Structural correlates of cognition in dementia: quantification and assessment of synapse change.

Authors:  S T DeKosky; S W Scheff; S D Styren
Journal:  Neurodegeneration       Date:  1996-12

8.  Antinociceptive and antiinflammatory effects of Niga-ichigoside F1 and 23-hydroxytormentic acid obtained from Rubus coreanus.

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Journal:  Biol Pharm Bull       Date:  2003-10       Impact factor: 2.233

Review 9.  Challenges for research on polyphenols from foods in Alzheimer's disease: bioavailability, metabolism, and cellular and molecular mechanisms.

Authors:  Manjeet Singh; Madeleine Arseneault; Thomas Sanderson; Ven Murthy; Charles Ramassamy
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10.  Effects of a Rubus coreanus Miquel supplement on plasma antioxidant capacity in healthy Korean men.

Authors:  Ji Eun Lee; Eunkyo Park; Jung Eun Lee; Joong Hyuck Auh; Hyung-Kyoon Choi; Jaehwi Lee; Soomuk Cho; Jung-Hyun Kim
Journal:  Nutr Res Pract       Date:  2011-10-28       Impact factor: 1.926
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  2 in total

1.  Phytochemical Composition and Biological Activities of Selected Wild Berries (Rubus moluccanus L., R. fraxinifolius Poir., and R. alpestris Blume).

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Journal:  Evid Based Complement Alternat Med       Date:  2016-06-28       Impact factor: 2.629

2.  Rubi Fructus Water Extract Alleviates LPS-Stimulated Macrophage Activation via an ER Stress-Induced Calcium/CHOP Signaling Pathway.

Authors:  Do-Hoon Kim; Ji-Young Lee; Young-Jin Kim; Hyun-Ju Kim; Wansu Park
Journal:  Nutrients       Date:  2020-11-22       Impact factor: 5.717
  2 in total

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