Literature DB >> 91175

Immune response genes have a variable influence on the selection of antigenic foreign and self determinants of insulin.

I R Cohen, J Talmon, V Lev-Ram, A Ben-Nun.   

Abstract

We studied the proliferative response of mouse T lymphocytes to determinants on ungulate insulins. The immunopotency of defined determinants on the molecule was found to be regulated by three factors: the immune response genes of the immunized mouse, the mode of presentation of insulin on cells or in adjuvant, and the intramolecular cooperativity between different determinants on the insulin molecule. Autosensitization against self determinants was observed under specific conditions. These findings emphasize the variable expression of immune response genes.

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Year:  1979        PMID： 91175      PMCID： PMC383978          DOI： 10.1073/pnas.76.8.4066

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  19 in total

1.  Determinant selection is a macrophage dependent immune response gene function.

Authors:  A S Rosenthal; M A Barcinski; J T Blake
Journal:  Nature       Date:  1977-05-12       Impact factor: 49.962

2.  Antigenic competition and genetic control of the immune response. A hypothesis for intramolecular competition.

Authors:  M J Taussig; E Mozes; G M Shearer; M Sela
Journal:  Cell Immunol       Date:  1973-08       Impact factor: 4.868

3.  Mouse insulins--separation and structures.

Authors:  J Markussen
Journal:  Int J Protein Res       Date:  1971

4.  Regulation of autosensitisation to encephalitogenic myelin basic protein by macrophage-association and soluble antigen.

Authors:  L Steinman; I R Cohen; D Teitelbaum; R Arnon
Journal:  Nature       Date:  1977-01-13       Impact factor: 49.962

5.  Ir-gene control of immunogenicity of insulin and A-chain loop as a carrier determinant.

Authors:  K Keck
Journal:  Nature       Date:  1975-03-06       Impact factor: 49.962

6.  Cellular analysis of the phenotypic correction of the genetically controlled low immune response to the polyproline determinant by macrophages.

Authors:  F W Falkenberg; A Sulica; G M Shearer; E Mozes; M Sela
Journal:  Cell Immunol       Date:  1974-05       Impact factor: 4.868

7.  Autoimmune encephalomyelitis: activation of thymus lymphocytes against syngeneic brain antigens in vitro.

Authors:  S Orgad; I R Cohen
Journal:  Science       Date:  1974-03-15       Impact factor: 47.728

8.  Mapping of the residues responsible for the negative cooperativity of the receptor-binding region of insulin.

Authors:  P De Meyts; E Van Obberghen; J Roth
Journal:  Nature       Date:  1978-06-15       Impact factor: 49.962

9.  Antigen presentation in the murine T-lymphocyte proliferative response. I. Requirement for genetic identity at the major histocompatibility complex.

Authors:  A Yano; R H Schwartz; W E Paul
Journal:  J Exp Med       Date:  1977-09-01       Impact factor: 14.307

10.  Secondary antibody responses in vitro to L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) by (responder X nonresponder)F1 spleen cells stimulated by parental GAT-macrophages.

Authors:  C W Pierce; R N Germain; J A Kapp; B Benacerraf
Journal:  J Exp Med       Date:  1977-12-01       Impact factor: 14.307
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  10 in total

1.  Reversal of H-2-restricted hyporesponsiveness to human growth hormone by the use of aluminum hydroxide as adjuvant.

Authors:  R Bomford; R Aston; J Ivanyi
Journal:  Immunogenetics       Date:  1985       Impact factor: 2.846

2.  Structural analysis of insulin determinants seen by T cells directed by H-2 genes.

Authors:  J Talmon; G Ranghino; A Yonath; I R Cohen
Journal:  Immunogenetics       Date:  1983       Impact factor: 2.846

3.  Thymic reconstitution of H-2-linked T-cell responses to thyroglobulin or insulin.

Authors:  R Maron; I R Cohen
Journal:  Immunogenetics       Date:  1983       Impact factor: 2.846

4.  Molecular events in the processing of avidin by antigen-presenting cells (APC). III. Activation of T-lymphocyte lines and H-2 restriction are mediated by processed avidin associated with I-region gene products.

Authors:  A Friedman; R Zerubavel; C Gitler; I R Cohen
Journal:  Immunogenetics       Date:  1983       Impact factor: 2.846

5.  Analysis of the in vitro immune response to insulin. I. Primary induction of insulin-specific T helper cells and characterization of the genetic control of the helper cell response to bovine and porcine insulin.

Authors:  P Erb
Journal:  Immunology       Date:  1980-07       Impact factor: 7.397

6.  Mutations at H-2K or H-2D alter immune response phenotype of autoimmune thyroiditis.

Authors:  R Maron; J Klein; I R Cohen
Journal:  Immunogenetics       Date:  1982       Impact factor: 2.846

7.  T cell Ir phenotype modified by excising primary antigen deposit.

Authors:  A Friedman; I R Cohen
Journal:  Immunogenetics       Date:  1984       Impact factor: 2.846

8.  Molecular events in the processing of avidin by antigen-presenting cells (APC). II. Identical processing by APC of H-2 high- and low-responder mouse strains.

Authors:  A Friedman; R Zerubavel; C Gitler; I R Cohen
Journal:  Immunogenetics       Date:  1983       Impact factor: 2.846

9.  Xid-defective male (CBA/N X C57BL/6)F1 accessory cells present bovine insulin to long-term cultured F1-restricted T-cells.

Authors:  A B Reske-Kunz; I Iskandar; H G Gattner; D Brandenburg; E Rüde
Journal:  Immunogenetics       Date:  1982       Impact factor: 2.846

10.  Molecular events in the processing of avidin by antigen-presenting cells (APC). I. The immune response of T lymphocytes to avidin is regulated by H-2-linked Ir genes.

Authors:  A Friedman; I R Cohen
Journal:  Immunogenetics       Date:  1983       Impact factor: 2.846
  10 in total

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