Literature DB >> 6190746

Structural analysis of insulin determinants seen by T cells directed by H-2 genes.

J Talmon, G Ranghino, A Yonath, I R Cohen.   

Abstract

The magnitude of the immune response of lymphocytes to defined antigenic determinants of ungulate insulins is controlled by the products of H-2 genes. Based on the crystallographically solved structure of porcine insulin, the close homology of all the ungulate insulins, and the amino acid substitutions, we built models of the different insulins. We analyzed the likely conformations of the antigenic determinants, and proposed structural specificities accounting for the immunologic phenomena observed.

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Year:  1983        PMID： 6190746     DOI： 10.1007/bf00401358

Source DB:  PubMed          Journal:  Immunogenetics        ISSN： 0093-7711            Impact factor:   2.846


  19 in total

1.  Structure of insulin in 4-zinc insulin.

Authors:  G Bentley; E Dodson; G Dodson; D Hodgkin; D Mercola
Journal:  Nature       Date:  1976-05-13       Impact factor: 49.962

2.  Preparation and properties of crystals of a Bence-Jones dimer with mercury inserted into the interchain disulfide bond.

Authors:  K R Ely; R L Girling; M Schiffer; D E Cunningham; A B Edmundson
Journal:  Biochemistry       Date:  1973-10-09       Impact factor: 3.162

3.  Structure of a lambda-type Bence-Jones protein at 3.5-A resolution.

Authors:  M Schiffer; R L Girling; K R Ely; A B Edmundson
Journal:  Biochemistry       Date:  1973-11-06       Impact factor: 3.162

Review 4.  The antigenic structure of myoglobin and initial consequences of its precise determination.

Authors:  M Z Atassi
Journal:  CRC Crit Rev Biochem       Date:  1979

5.  Structural relationships in the two-zinc insulin hexamer.

Authors:  E J Dodson; G G Dodson; D C Hodgkin; C D Reynolds
Journal:  Can J Biochem       Date:  1979-06

6.  The three dimensional structure of a combining region-ligand complex of immunoglobulin NEW at 3.5-A resolution.

Authors:  L M Amzel; R J Poljak; F Saul; J M Varga; F F Richards
Journal:  Proc Natl Acad Sci U S A       Date:  1974-04       Impact factor: 11.205

7.  Immune response gene control of determinant selection. II. Genetic control of the murine T lymphocyte proliferative response to insulin.

Authors:  L J Rosenwasser; M A Barcinski; R H Schwartz; A S Rosenthal
Journal:  J Immunol       Date:  1979-07       Impact factor: 5.422

8.  Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants. I. Demonstration of similar or identical idiotypes on IgG molecules and T-cell receptors with specificity for the same alloantigens.

Authors:  H Binz; H Wigzell
Journal:  J Exp Med       Date:  1975-07-01       Impact factor: 14.307

9.  Responder T cells depleted of alloreactive cells react to antigen presented on allogeneic macrophages from nonresponder strains.

Authors:  N Ishii; C N Baxevanis; Z A Nagy; J Klein
Journal:  J Exp Med       Date:  1981-09-01       Impact factor: 14.307
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  3 in total

1.  Recognition of human insulin in vitro by T cells from subjects treated with animal insulins.

Authors:  L J Nell; V J Virta; J W Thomas
Journal:  J Clin Invest       Date:  1985-12       Impact factor: 14.808

2.  T cell Ir phenotype modified by excising primary antigen deposit.

Authors:  A Friedman; I R Cohen
Journal:  Immunogenetics       Date:  1984       Impact factor: 2.846

3.  Identification of an autologous insulin B chain peptide as a target antigen for H-2Kb-restricted cytotoxic T lymphocytes.

Authors:  J M Sheil; S E Shepherd; G F Klimo; Y Paterson
Journal:  J Exp Med       Date:  1992-02-01       Impact factor: 14.307
  3 in total

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