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Literature DB >> 911650

Effects of nomifensine in vitro on uptake of 5-hydroxytryptamine and dopamine into human platelets.

Abstract

1. The effect of nomifensine on the uptake of 5-hydroxytryptamine (5-HT) and dopamine (DA) into human platelet-rich plasma has been studied. 2. A significant inhibition of DA uptake was observed at nomifensine 10(-6) M. 3. 5-HT uptake was significantly inhibited only at nomifensine 10(-4) M or more. 4. These results are consistent with those from previous animal experiments and suggest that the human platelet may be used as a model for studying DA uptake as well as that of 5-HT.

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Year: 1977 PMID： 911650 PMCID： PMC1429134 DOI： 10.1111/j.1365-2125.1977.tb05745.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

11 in total

1. PLATELET SEQUESTRATION IN MAN. I. METHODS.

Authors: R H ASTER; J H JANDL
Journal: J Clin Invest Date: 1964-05 Impact factor: 14.808

2. [Results of an open and a double-blind study of nomifensin in comparison to imipramin (author's transl)].

Authors: J Angst; M Koukkou; M Bleuler-Herzog; H Martens
Journal: Arch Psychiatr Nervenkr (1970) Date: 1974

3. Effect of nomifensine on motor activity, dopamine turnover rate and cyclic 3',5;-adenosine monophosphate concentrations of rat striatum.

Authors: H J Gerhards; A Carenzi; E Costa
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1974 Impact factor: 3.000

Review 4. Blood platelets as a model for monoamine-containing neurones.

Authors: J M Sneddon
Journal: Prog Neurobiol Date: 1973 Impact factor: 11.685

5. 8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline, a new antidepressant.

Authors: I Hoffmann
Journal: Arzneimittelforschung Date: 1973-01

6. [8-amino-4-phenyl-1,2,3,4-tetrahydroisoquinolines, a new group of antidepressive psycholeptic drugs].

Authors: I Hoffmann; G Ehrhart; K Schmitt
Journal: Arzneimittelforschung Date: 1971-07

7. Nomifensine: a potent dopaminergic agonist of antiparkinson potential.

Authors: B Costall; D M Kelly; R J Naylor
Journal: Psychopharmacologia Date: 1975

8. Nomifensine: a new potent inhibitor of dopamine uptake into synaptosomes from rat brain corpus striatum.

Authors: P Hunt; M Kannengiesser; J Raynaud
Journal: J Pharm Pharmacol Date: 1974-05 Impact factor: 3.765

9. Biochemical and histochemical studies on the effects of imipramine-like drugs and (+)-amphetamine on central and peripheral catecholamine neurons.

Authors: A Carlsson; K Fuxe; B Hamberger; M Lindqvist
Journal: Acta Physiol Scand Date: 1966 Jul-Aug

Effects of nomifensine in vitro on uptake of 5-hydroxytryptamine and dopamine into human platelets.

1. PLATELET SEQUESTRATION IN MAN. I. METHODS.

2. [Results of an open and a double-blind study of nomifensin in comparison to imipramin (author's transl)].

3. Effect of nomifensine on motor activity, dopamine turnover rate and cyclic 3',5;-adenosine monophosphate concentrations of rat striatum.

Review 4. Blood platelets as a model for monoamine-containing neurones.

5. 8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline, a new antidepressant.

6. [8-amino-4-phenyl-1,2,3,4-tetrahydroisoquinolines, a new group of antidepressive psycholeptic drugs].

7. Nomifensine: a potent dopaminergic agonist of antiparkinson potential.

8. Nomifensine: a new potent inhibitor of dopamine uptake into synaptosomes from rat brain corpus striatum.

9. Biochemical and histochemical studies on the effects of imipramine-like drugs and (+)-amphetamine on central and peripheral catecholamine neurons.

10. Clinical pharmacological studies of tandamine, a potential antidepressive drug.

1. Influence of ciclazindol on monoamine uptake and CNS function in normal subjects.

2. A comparison of the pharmacodynamic profiles of nomifensine and amitriptyline in normal subjects.

3. Enhanced attention in rhesus monkeys as a common factor for the cognitive effects of drugs with abuse potential.

4. Dopamine uptake in platelets: two different low-affinity, saturable mechanisms.

5. Nomifensine: A review of its pharmacological properties and therapeutic efficacy in depressive illness.

6. Platelet monoamine uptake in relatives of patients with Huntington's chorea.