Literature DB >> 9115709

Gentamicin ototoxicity induced apoptosis of the vestibular hair cells of guinea pigs.

T Nakagawa1, H Yamane, S Shibata, Y Nakai.   

Abstract

To clarify mechanisms of inner ear cell death induced by aminoglycosides, we used an in situ nick-end labelling method to examine guinea pig vestibular epithelia after chronic systemic treatments with gentamicin to produce apoptosis. Such changes occurred in damaged hair cells, suggesting that this process may be crucial for subsequent repair and cell regeneration.

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Year:  1997        PMID： 9115709     DOI： 10.1007/bf02630749

Source DB:  PubMed          Journal:  Eur Arch Otorhinolaryngol        ISSN： 0937-4477            Impact factor:   2.503


  23 in total

1.  Macrophages and glia participate in the removal of apoptotic neurons from the Drosophila embryonic nervous system.

Authors:  M J Sonnenfeld; J R Jacobs
Journal:  J Comp Neurol       Date:  1995-09-04       Impact factor: 3.215

2.  Induction of cell proliferation in mammalian inner-ear sensory epithelia by transforming growth factor alpha and epidermal growth factor.

Authors:  H Yamashita; E C Oesterle
Journal:  Proc Natl Acad Sci U S A       Date:  1995-04-11       Impact factor: 11.205

3.  Ultrastructural evidence for hair cell regeneration in the mammalian inner ear.

Authors:  A Forge; L Li; J T Corwin; G Nevill
Journal:  Science       Date:  1993-03-12       Impact factor: 47.728

Review 4.  Cell death: the significance of apoptosis.

Authors:  A H Wyllie; J F Kerr; A R Currie
Journal:  Int Rev Cytol       Date:  1980

5.  In vivo regeneration of vestibular hair cells of guinea pig.

Authors:  H Yamane; T Nakagawa; H Iguchi; S Shibata; M Takayama; K Nishimura; Y Nakai
Journal:  Acta Otolaryngol Suppl       Date:  1995

6.  An electron-microscope study of the mode of cell death induced by cancer-chemotherapeutic agents in populations of proliferating normal and neoplastic cells.

Authors:  J Searle; T A Lawson; P J Abbott; B Harmon; J F Kerr
Journal:  J Pathol       Date:  1975-07       Impact factor: 7.996

7.  Apoptosis in the normal olfactory epithelium of the adult guinea pig.

Authors:  T Nakagawa; T Aiba; H Shiotani; K Tomiyama; Y Nakai
Journal:  Eur Arch Otorhinolaryngol       Date:  1996       Impact factor: 2.503

8.  Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans.

Authors:  M E Warchol; P R Lambert; B J Goldstein; A Forge; J T Corwin
Journal:  Science       Date:  1993-03-12       Impact factor: 47.728

9.  Two modes of hair cell loss from the vestibular sensory epithelia of the guinea pig inner ear.

Authors:  L Li; G Nevill; A Forge
Journal:  J Comp Neurol       Date:  1995-05-08       Impact factor: 3.215

Review 10.  Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.

Authors:  J F Kerr; A H Wyllie; A R Currie
Journal:  Br J Cancer       Date:  1972-08       Impact factor: 7.640
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  14 in total

1.  Immunocytochemical and morphological evidence for intracellular self-repair as an important contributor to mammalian hair cell recovery.

Authors:  J L Zheng; G Keller; W Q Gao
Journal:  J Neurosci       Date:  1999-03-15       Impact factor: 6.167

2.  Loss of Afferent Vestibular Input Produces Central Adaptation and Increased Gain of Vestibular Prosthetic Stimulation.

Authors:  Christopher Phillips; Sarah J Shepherd; Amy Nowack; Kaibao Nie; Chris R S Kaneko; Jay T Rubinstein; Leo Ling; James O Phillips
Journal:  J Assoc Res Otolaryngol       Date:  2015-10-05

3.  Localization of gentamicin uptake in the acutely isolated inner ear of the rat.

Authors:  Katharina Schmid; Jürgen Strutz; Otto Gleich; Pingling Kwok
Journal:  Int J Physiol Pathophysiol Pharmacol       Date:  2011-03-28

4.  Spontaneous and Partial Repair of Ribbon Synapse in Cochlear Inner Hair Cells After Ototoxic Withdrawal.

Authors:  Ke Liu; DaiShi Chen; WeiWei Guo; Ning Yu; XiaoYu Wang; Fei Ji; ZhaoHui Hou; Wei-Yan Yang; ShiMing Yang
Journal:  Mol Neurobiol       Date:  2014-11-07       Impact factor: 5.590

5.  Inhibition of caspases prevents ototoxic and ongoing hair cell death.

Authors:  Jonathan I Matsui; Judith M Ogilvie; Mark E Warchol
Journal:  J Neurosci       Date:  2002-02-15       Impact factor: 6.167

6.  Cell death caused by the acute effects of aminoglycoside and zinc in the ampullary cristae of guinea pigs.

Authors:  T Nakagawa; H Yamane; S Shibata; K Sunami; Y Nakai
Journal:  Eur Arch Otorhinolaryngol       Date:  1997       Impact factor: 2.503

7.  Gentamicin is primarily localized in vestibular type I hair cells after intratympanic administration.

Authors:  Sofia Lyford-Pike; Casey Vogelheim; Eugene Chu; Charles C Della Santina; John P Carey
Journal:  J Assoc Res Otolaryngol       Date:  2007-09-25

8.  Cochlear inner hair cell ribbon synapse is the primary target of ototoxic aminoglycoside stimuli.

Authors:  Ke Liu; Xuejun Jiang; Chuang Shi; Lei Shi; Bo Yang; Lin Shi; Yice Xu; Weiyan Yang; Shiming Yang
Journal:  Mol Neurobiol       Date:  2013-04-20       Impact factor: 5.590

9.  Gentamicin administration on the stapes footplate causes greater hearing loss and vestibulotoxicity than round window administration in guinea pigs.

Authors:  E B King; A N Salt; G E Kel; H T Eastwood; S J O'Leary
Journal:  Hear Res       Date:  2013-07-27       Impact factor: 3.208

10.  Effect of different gentamicin dose on the plasticity of the ribbon synapses in cochlear inner hair cells of C57BL/6J mice.

Authors:  Liping Chen; Siqing Xiong; Yi Liu; Xiuli Shang
Journal:  Mol Neurobiol       Date:  2012-08-04       Impact factor: 5.590
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