| Literature DB >> 9113327 |
T Hayashi1, B W Murray, R Wang, C H Wong.
Abstract
Uridine 5'-diphospho-(2-deoxy-2-fluoro)galactose (UDP-2FGal), prepared and characterized for the first time by a chemoenzymatic method, was found to be a competitive inhibitor of beta-1,4-galactosyltransferase with a Ki value of 149 microM. This study supports that the glycosyltransferase reaction mechanism proceeds through a glycosidic cleavage transition state with sp2 character developed at the anomeric center.Entities:
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Year: 1997 PMID： 9113327 DOI： 10.1016/s0968-0896(96)00263-5
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641