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Literature DB >> 26023910

Efficient chemoenzymatic synthesis of novel galacto-N-biose derivatives and their sialylated forms.

Lei Li¹, Yonghui Liu, Tiehai Li, Wenjun Wang, Zaikuan Yu, Cheng Ma, Jingyao Qu, Wei Zhao, Xi Chen, Peng G Wang.

Abstract

Galacto-N-biose (GNB) derivatives were efficiently synthesized from galactose derivatives via a one-pot two-enzyme system containing two promiscuous enzymes from Bifidobacterium infantis: a galactokinase (BiGalK) and a d-galactosyl-β1-3-N-acetyl-d-hexosamine phosphorylase (BiGalHexNAcP). Mono-sialyl and di-sialyl galacto-N-biose derivatives were then prepared using a one-pot two-enzyme system containing a CMP-sialic acid synthetase and an α2-3-sialyltransferase or an α2-6-sialyltransferase.

Entities: Chemical Disease Gene Mutation Species

Mesh：

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Year: 2015 PMID： 26023910 PMCID： PMC4498953 DOI： 10.1039/c5cc03746h

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

31 in total

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Authors: Yuriy A Knirel; Andrei V Perepelov; Anna N Kondakova; Sof'ya N Senchenkova; Zygmunt Sidorczyk; Antoni Rozalski; Wieslaw Kaca
Journal: Innate Immun Date: 2010-03-19 Impact factor: 2.680

3. A multifunctional Pasteurella multocida sialyltransferase: a powerful tool for the synthesis of sialoside libraries.

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Authors: Ronald L Schnaar
Journal: FEBS Lett Date: 2009-10-12 Impact factor: 4.124

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Authors: G Baisch; R Ohrlein; M Streiff; F Kolbinger
Journal: Bioorg Med Chem Lett Date: 1998-04-07 Impact factor: 2.823

6. Synthesis of 2-acetamido-2-deoxy-3-O-beta-D-galactopyranosyl-D-galacto se by the sequential use of beta-D-galactosidases from bovine testes and Escherichia coli.

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Journal: Carbohydr Res Date: 1989-03-15 Impact factor: 2.104

7. Chemo-enzymatic synthesis of fluorinated sugar nucleotide: useful mechanistic probes for glycosyltransferases.

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Review 8. Structure and genetics of Shigella O antigens.

Authors: Bin Liu; Yuriy A Knirel; Lu Feng; Andrei V Perepelov; Sof'ya N Senchenkova; Quan Wang; Peter R Reeves; Lei Wang
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9. A sialyltransferase mutant with decreased donor hydrolysis and reduced sialidase activities for directly sialylating LewisX.

Authors: Go Sugiarto; Kam Lau; Jingyao Qu; Yanhong Li; Sunghyuk Lim; Shengmao Mu; James B Ames; Andrew J Fisher; Xi Chen
Journal: ACS Chem Biol Date: 2012-05-14 Impact factor: 5.100

Efficient chemoenzymatic synthesis of novel galacto-N-biose derivatives and their sialylated forms.

Review 1. Combinatorial ganglioside biosynthesis.

Review 2. Structure and serology of O-antigens as the basis for classification of Proteus strains.

3. A multifunctional Pasteurella multocida sialyltransferase: a powerful tool for the synthesis of sialoside libraries.

Review 4. Brain gangliosides in axon-myelin stability and axon regeneration.

5. On the preparative use of recombinant beta(1-3)galactosyl-transferase.

6. Synthesis of 2-acetamido-2-deoxy-3-O-beta-D-galactopyranosyl-D-galacto se by the sequential use of beta-D-galactosidases from bovine testes and Escherichia coli.

7. Chemo-enzymatic synthesis of fluorinated sugar nucleotide: useful mechanistic probes for glycosyltransferases.

Review 8. Structure and genetics of Shigella O antigens.

9. A sialyltransferase mutant with decreased donor hydrolysis and reduced sialidase activities for directly sialylating LewisX.

10. Regioselective chemoenzymatic synthesis of ganglioside disialyl tetrasaccharide epitopes.

1. One-pot multienzyme (OPME) systems for chemoenzymatic synthesis of carbohydrates.

2. Biochemical characterization of an α1,2-colitosyltransferase from Escherichia coli O55:H7.

Review 3. Glycan Phosphorylases in Multi-Enzyme Synthetic Processes.

4. Facile and Stereo-Selective Synthesis of UDP-α-D-xylose and UDP-β-L-arabinose Using UDP-Sugar Pyrophosphorylase.

5. Unravelling the Role of O-glycans in Influenza A Virus Infection.