Literature DB >> 9107053

Maximum likelihood estimation of aggregated Markov processes.

F Qin1, A Auerbach, F Sachs.   

Abstract

We present a maximum likelihood method for the modelling of aggregated Markov processes. The method utilizes the joint probability density of the observed dwell time sequence as likelihood. A forward-backward recursive procedure is developed for efficient computation of the likelihood function and its derivatives with respect to the model parameters. Based on the calculated forward and backward vectors, analytical formulae for the derivatives of the likelihood function are derived. The method exploits the variable metric optimizer for search of the likelihood space. It converges rapidly and is numerically stable. Numerical examples are given to show the effectiveness of the method.

Mesh:

Year:  1997        PMID: 9107053      PMCID: PMC1688268          DOI: 10.1098/rspb.1997.0054

Source DB:  PubMed          Journal:  Proc Biol Sci        ISSN: 0962-8452            Impact factor:   5.349


  13 in total

1.  Maximum likelihood estimation and identification directly from single-channel recordings.

Authors:  D R Fredkin; J A Rice
Journal:  Proc Biol Sci       Date:  1992-08-22       Impact factor: 5.349

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Authors:  R Horn
Journal:  Biophys J       Date:  1987-02       Impact factor: 4.033

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Authors:  F Qin; A Auerbach; F Sachs
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4.  Internal motions in proteins and gating kinetics of ionic channels.

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Journal:  Biophys J       Date:  1988-06       Impact factor: 4.033

5.  Ion-channel gating mechanisms: model identification and parameter estimation from single channel recordings.

Authors:  F G Ball; M S Sansom
Journal:  Proc R Soc Lond B Biol Sci       Date:  1989-05-22

6.  On the stochastic properties of bursts of single ion channel openings and of clusters of bursts.

Authors:  D Colquhoun; A G Hawkes
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1982-12-24       Impact factor: 6.237

7.  Capacitance measurements reveal stepwise fusion events in degranulating mast cells.

Authors:  J M Fernandez; E Neher; B D Gomperts
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8.  Estimating kinetic constants from single channel data.

Authors:  R Horn; K Lange
Journal:  Biophys J       Date:  1983-08       Impact factor: 4.033

9.  Calcium dependence of open and shut interval distributions from calcium-activated potassium channels in cultured rat muscle.

Authors:  K L Magleby; B S Pallotta
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10.  A statistical analysis of acetylcholine receptor activation in Xenopus myocytes: stepwise versus concerted models of gating.

Authors:  A Auerbach
Journal:  J Physiol       Date:  1993-02       Impact factor: 5.182

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  157 in total

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5.  The effects of non-identifiability on testing for detailed balance in aggregated Markov models for ion-channel gating.

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8.  Applying hidden Markov models to the analysis of single ion channel activity.

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9.  Markovian models of low and high activity levels of cardiac ryanodine receptors.

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Journal:  Biophys J       Date:  2001-06       Impact factor: 4.033

10.  Structural elements near the C-terminus are responsible for changes in nicotinic receptor gating kinetics following patch excision.

Authors:  G Akk; J H Steinbach
Journal:  J Physiol       Date:  2000-09-15       Impact factor: 5.182

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