Literature DB >> 9105910

Posttraumatic stress disorder: a sensitization reaction.

R A Dykman1, P T Ackerman, J E Newton.   

Abstract

This article discusses past research bearing on the question of the etiology of Posttraumatic Stress Disorder (PTSD). It argues that PTSD can be adequately accounted for by a process of emotional sensitization and that this is a more parsimonious explanation than the two-factor learning theory of Mowrer, now postulated by several writers. In brief, the etiology and subsequent development of PTSD is viewed as the result of the sensitization of fear/anxiety which is linked to a variety of to be conditional stimuli by both backward and forward association: these become conditional stimuli (CSi) once paired with the instigating circumstances. It is furthermore assumed that PTSD will not occur in the absence of a genetic susceptibility that may vary from zero to absolute certainty. Thus far, our evidence is limited to a sensitivity to loud sounds, but it is highly probable that touch and other sensory systems are involved (not necessarily in parallel). The fact that abuse often leads to behavioral disorders, including sexually seductive behaviors in children sexually abused, requires a recognition that emotional reactions other than fear may be sensitized. Fear in combination with pleasure or pleasure alone coupled with a loss of self-esteem may explain these acting-out behaviors.

Entities:  

Mesh:

Year:  1997        PMID: 9105910     DOI: 10.1007/bf02688609

Source DB:  PubMed          Journal:  Integr Physiol Behav Sci        ISSN: 1053-881X


  16 in total

1.  Chronic treatment with fluoxetine prevents the return of extinguished auditory-cued conditioned fear.

Authors:  Olivier Deschaux; Guillaume Spennato; Jean-Luc Moreau; René Garcia
Journal:  Psychopharmacology (Berl)       Date:  2010-12-22       Impact factor: 4.530

2.  Nonassociative learning processes determine expression and extinction of conditioned fear in mice.

Authors:  Kornelia Kamprath; Carsten T Wotjak
Journal:  Learn Mem       Date:  2004-11-10       Impact factor: 2.460

3.  Effects of paroxetine on PTSD-like symptoms in mice.

Authors:  Yassine Bentefour; Mohamed Bennis; René Garcia; Saadia Ba M'hamed
Journal:  Psychopharmacology (Berl)       Date:  2015-01-15       Impact factor: 4.530

4.  Internalizing and externalizing characteristics of sexually and/or physically abused children.

Authors:  R A Dykman; B McPherson; P T Ackerman; J E Newton; D M Mooney; J Wherry; M Chaffin
Journal:  Integr Physiol Behav Sci       Date:  1997 Jan-Mar

5.  Amygdala transcriptome and cellular mechanisms underlying stress-enhanced fear learning in a rat model of posttraumatic stress disorder.

Authors:  Igor Ponomarev; Vinuta Rau; Edmond I Eger; R Adron Harris; Michael S Fanselow
Journal:  Neuropsychopharmacology       Date:  2010-02-10       Impact factor: 7.853

6.  Distinct Hippocampal Expression Profiles of lncRNAs in Rats Exhibiting a PTSD-like Syndrome.

Authors:  Liu Qingzhen; Ma Jiehua; Yu Zhiyang; Liu Hongjun; Chen Chunlong; Li Weiyan
Journal:  Mol Neurobiol       Date:  2015-05-05       Impact factor: 5.590

7.  Fluoxetine protects hippocampal plasticity during conditioned fear stress and prevents fear learning potentiation.

Authors:  Guillaume Spennato; Carine Zerbib; Cesare Mondadori; René Garcia
Journal:  Psychopharmacology (Berl)       Date:  2007-11-09       Impact factor: 4.530

Review 8.  Induction and Expression of Fear Sensitization Caused by Acute Traumatic Stress.

Authors:  Jennifer N Perusini; Edward M Meyer; Virginia A Long; Vinuta Rau; Nathaniel Nocera; Jacob Avershal; James Maksymetz; Igor Spigelman; Michael S Fanselow
Journal:  Neuropsychopharmacology       Date:  2015-08-06       Impact factor: 7.853

9.  Effects of oxytocin on methamphetamine-seeking exacerbated by predator odor pre-exposure in rats.

Authors:  Chantelle L Ferland; Carmela M Reichel; Jacqueline F McGinty
Journal:  Psychopharmacology (Berl)       Date:  2015-12-23       Impact factor: 4.530

10.  Stress-Enhanced Fear Learning, a Robust Rodent Model of Post-Traumatic Stress Disorder.

Authors:  Abha K Rajbhandari; Sarah T Gonzalez; Michael S Fanselow
Journal:  J Vis Exp       Date:  2018-10-13       Impact factor: 1.355

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.