| Literature DB >> 9105759 |
Abstract
The role of dendritic cells (DC) in the pathogenesis of human immunodeficiency virus (HIV) disease has been a subject of considerable interest for several years. Initial studies focused on the infection, dysfunction, and depletion of DC in HIV-infected individuals. More recent studies have begun to identify the functional role of DC in the initiation and propagation of viral replication in T cells in HIV-infected individuals. This review discusses recent data regarding the role of DC in HIV disease with the aim of delineating basic immunopathogenic principles of infection and the development of therapeutic strategies.Entities:
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Year: 1997 PMID: 9105759 PMCID: PMC172924 DOI: 10.1128/CMR.10.2.358
Source DB: PubMed Journal: Clin Microbiol Rev ISSN: 0893-8512 Impact factor: 26.132