Literature DB >> 14557658

The AIDS-like disease of CD4C/human immunodeficiency virus transgenic mice is associated with accumulation of immature CD11bHi dendritic cells.

Johanne Poudrier1, Xiaoduan Weng, Denis G Kay, Zaher Hanna, Paul Jolicoeur.   

Abstract

CD4C/human immunodeficiency virus (HIV) transgenic mice develop an AIDS-like disease. We used this model to study the effects of HIV-1 on dendritic cells (DC). We found a progressive decrease in total DC numbers in the lymph nodes, with a significant accumulation of CD11b(Hi) DC. In the thymus, the recovery of transgenic CD8alpha(+) DC had a tendency to be lower. Spleen DC were augmented in the marginal zone. Transgenic DC showed a decreased capacity to present antigen in vitro, consistent with their reduced major histocompatibility complex class II expression and impaired maturation profile. The accumulation of immature DC may contribute to disease and may reflect an adaptive advantage for the virus by favoring its replication and preventing the generation of fully functional antiviral responses.

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Year:  2003        PMID： 14557658      PMCID： PMC229375          DOI： 10.1128/jvi.77.21.11733-11744.2003

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  89 in total

1.  HIV-1 Nef-induced upregulation of DC-SIGN in dendritic cells promotes lymphocyte clustering and viral spread.

Authors:  Nathalie Sol-Foulon; Arnaud Moris; Cinzia Nobile; Claire Boccaccio; Anneke Engering; Jean-Pierre Abastado; Jean-Michel Heard; Yvette van Kooyk; Olivier Schwartz
Journal:  Immunity       Date:  2002-01       Impact factor: 31.745

2.  HIV-1 Nef impairs MHC class II antigen presentation and surface expression.

Authors:  P Stumptner-Cuvelette; S Morchoisne; M Dugast; S Le Gall; G Raposo; O Schwartz; P Benaroch
Journal:  Proc Natl Acad Sci U S A       Date:  2001-10-02       Impact factor: 11.205

3.  Reduced blood CD123+ (lymphoid) and CD11c+ (myeloid) dendritic cell numbers in primary HIV-1 infection.

Authors:  J Pacanowski; S Kahi; M Baillet; P Lebon; C Deveau; C Goujard; L Meyer; E Oksenhendler; M Sinet; A Hosmalin
Journal:  Blood       Date:  2001-11-15       Impact factor: 22.113

4.  The AIDS disease of CD4C/HIV transgenic mice shows impaired germinal centers and autoantibodies and develops in the absence of IFN-gamma and IL-6.

Authors:  J Poudrier; X Weng; D G Kay; G Paré; E L Calvo; Z Hanna; M H Kosco-Vilbois; P Jolicoeur
Journal:  Immunity       Date:  2001-08       Impact factor: 31.745

5.  Distinct regulatory elements are required for faithful expression of human CD4 in T cells, macrophages, and dendritic cells of transgenic mice.

Authors:  Z Hanna; N Rebai; J Poudrier; P Jolicoeur
Journal:  Blood       Date:  2001-10-01       Impact factor: 22.113

6.  Comparative loss and maturation of peripheral blood dendritic cell subpopulations in African and non-African HIV-1-infected patients.

Authors:  G J Jones; C Watera; S Patterson; A Rutebemberwa; P Kaleebu; J A Whitworth; F M Gotch; J W Gilmour
Journal:  AIDS       Date:  2001-09-07       Impact factor: 4.177

7.  Loss of blood CD11c(+) myeloid and CD11c(-) plasmacytoid dendritic cells in patients with HIV-1 infection correlates with HIV-1 RNA virus load.

Authors:  H Donaghy; A Pozniak; B Gazzard; N Qazi; J Gilmour; F Gotch; S Patterson
Journal:  Blood       Date:  2001-10-15       Impact factor: 22.113

8.  Mucosal candidiasis in transgenic mice expressing human immunodeficiency virus type 1.

Authors:  Louis de Repentigny; Francine Aumont; Jean-Sébastien Ripeau; Marie Fiorillo; Denis G Kay; Zaher Hanna; Paul Jolicoeur
Journal:  J Infect Dis       Date:  2002-03-21       Impact factor: 5.226

9.  Accumulation of DC-SIGN+CD40+ dendritic cells with reduced CD80 and CD86 expression in lymphoid tissue during acute HIV-1 infection.

Authors:  Karin Loré; Anders Sönnerborg; Christina Broström; Li-Ean Goh; Luc Perrin; Hugh McDade; Hans-Jürgen Stellbrink; Brian Gazzard; Rainer Weber; Laura A Napolitano; Yvette van Kooyk; Jan Andersson
Journal:  AIDS       Date:  2002-03-29       Impact factor: 4.177

10.  Downregulation of major histocompatibility class I on human dendritic cells by HIV Nef impairs antigen presentation to HIV-specific CD8+ T lymphocytes.

Authors:  M Andrieu; D Chassin; J F Desoutter; I Bouchaert; M Baillet; D Hanau; J G Guillet; A Hosmalin
Journal:  AIDS Res Hum Retroviruses       Date:  2001-09-20       Impact factor: 2.205
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  14 in total

1.  Human immunodeficiency virus type 1 Vpr impairs dendritic cell maturation and T-cell activation: implications for viral immune escape.

Authors:  Biswanath Majumder; Michelle L Janket; Elizabeth A Schafer; Keri Schaubert; Xiao-Li Huang; June Kan-Mitchell; Charles R Rinaldo; Velpandi Ayyavoo
Journal:  J Virol       Date:  2005-07       Impact factor: 5.103

2.  Overexpression of activated murine Notch1 and Notch3 in transgenic mice blocks mammary gland development and induces mammary tumors.

Authors:  Chunyan Hu; Anne Diévart; Mathieu Lupien; Ezequiel Calvo; Gilles Tremblay; Paul Jolicoeur
Journal:  Am J Pathol       Date:  2006-03       Impact factor: 4.307

3.  Primary human immunodeficiency virus type 1 nef alleles show major differences in pathogenicity in transgenic mice.

Authors:  Elena Priceputu; Zaher Hanna; Chunyan Hu; Marie-Chantal Simard; Patrick Vincent; Steffen Wildum; Michael Schindler; Frank Kirchhoff; Paul Jolicoeur
Journal:  J Virol       Date:  2007-02-21       Impact factor: 5.103

Review 4.  Immunopathogenesis of oropharyngeal candidiasis in human immunodeficiency virus infection.

Authors:  Louis de Repentigny; Daniel Lewandowski; Paul Jolicoeur
Journal:  Clin Microbiol Rev       Date:  2004-10       Impact factor: 26.132

5.  Selective expression of human immunodeficiency virus Nef in specific immune cell populations of transgenic mice is associated with distinct AIDS-like phenotypes.

Authors:  Zaher Hanna; Elena Priceputu; Pavel Chrobak; Chunyan Hu; Véronique Dugas; Mathieu Goupil; Miriam Marquis; Louis de Repentigny; Paul Jolicoeur
Journal:  J Virol       Date:  2009-07-15       Impact factor: 5.103

6.  CD4+ T cells from CD4C/HIVNef transgenic mice show enhanced activation in vivo with impaired proliferation in vitro but are dispensable for the development of a severe AIDS-like organ disease.

Authors:  Xiaoduan Weng; Elena Priceputu; Pavel Chrobak; Johanne Poudrier; Denis G Kay; Zaher Hanna; Tak W Mak; Paul Jolicoeur
Journal:  J Virol       Date:  2004-05       Impact factor: 5.103

7.  Altered immune response differentially enhances susceptibility to Cryptococcus neoformans and Cryptococcus gattii infection in mice expressing the HIV-1 transgene.

Authors:  Kassandre Leongson; Vincent Cousineau-Côté; Mathieu Goupil; Francine Aumont; Serge Sénéchal; Louis Gaboury; Paul Jolicoeur; James W Kronstad; Louis de Repentigny
Journal:  Infect Immun       Date:  2013-01-22       Impact factor: 3.441

8.  Dendritic cell status modulates the outcome of HIV-related B cell disease progression.

Authors:  Johanne Poudrier; Michel Roger
Journal:  PLoS Pathog       Date:  2011-08-25       Impact factor: 6.823

Review 9.  Influence of dendritic cells on B-cell responses during HIV infection.

Authors:  Johanne Poudrier; Josiane Chagnon-Choquet; Michel Roger
Journal:  Clin Dev Immunol       Date:  2012-02-22

10.  High expression levels of BLyS/BAFF by blood dendritic cells and granulocytes are associated with B-cell dysregulation in SIV-infected rhesus macaques.

Authors:  Johanne Poudrier; Caroline Soulas; Josiane Chagnon-Choquet; Tricia Burdo; Patrick Autissier; Kathryn Oskar; Kenneth C Williams; Michel Roger
Journal:  PLoS One       Date:  2015-06-24       Impact factor: 3.240
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