| Literature DB >> 910131 |
R J Rodriguez, R R White, R M Senior, E A Levine.
Abstract
Alveolar macrophages from smokers, in contrast to those of non-smokers, release elastase into serum-free culture medium. Since enzymes that digest elastin produce pulmonary emphysema in experimental animals, release of elastase by alveolar macrophages from smokers suggests that these cells are important in the pathogenesis of emphysema of smokers.Entities:
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Year: 1977 PMID： 910131 DOI： 10.1126/science.910131
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728