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Literature DB >> 7087960

Evidence for a noncholinergic nicotine receptor on human phagocytic leukocytes.

B D Davies, W Hoss, J P Lin, F Lionetti.

Abstract

A noncholinergic nicotine receptor on human phagocytic leukocytes has been characterized using the binding of 3H-(d,1)-nicotine. The average affinity +/- standard deviation of (d,1)-nicotine for the receptor on neutrophils is 36 +/- 18 nM (n = 6). The binding is saturable with an average of 8.7 x 10(4) sites per neutrophil. Monocytes and to a lesser extent lymphocytes but not erythrocytes also display specific binding. Bound nicotine is dissociable from the receptor and is not metabolized. Only close structural analogs of nicotine bind to the receptor, which is stereoselective for the (d)-isomer. The receptor can be occupied by (1)-nicotine at concentrations present in the blood of smokers. It is suggested that some of the adverse effects of smoking on leukocyte functions may be mediated by a specific nicotine receptor.

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Year: 1982 PMID： 7087960 DOI： 10.1007/BF00573842

Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396

22 in total

1. Effect of tobacco smoking on the functions of polymorphonuclear leukocytes.

Authors: J Corberand; F Nguyen; A H Do; G Dutau; P Laharrague; A M Fontanilles; B Gleizes
Journal: Infect Immun Date: 1979-03 Impact factor: 3.441

2. Demonstration that monocytes rather than lymphocytes are the insulin-binding cells in preparations of humah peripheral blood mononuclear leukocytes: implications for studies of insulin-resistant states in man.

Authors: R H Schwartz; A R Bianco; B S Handwerger; C R Kahn
Journal: Proc Natl Acad Sci U S A Date: 1975-02 Impact factor: 11.205

3. Elastase release from human alveolar macrophages: comparison between smokers and nonsmokers.

Authors: R J Rodriguez; R R White; R M Senior; E A Levine
Journal: Science Date: 1977-10-21 Impact factor: 47.728

4. Preservation of human granulocytes. II. Characteristics of granulocytes obtained by counterflow centrifugation.

Authors: F J Lionetti; S M Hunt; P S Lin; S R Kurtz; C R Valeri
Journal: Transfusion Date: 1977 Sep-Oct Impact factor: 3.157

5. Separation of granulocytes from peripheral blood in a single step using discontinuous density gradients of Ficoll-Urografin. A comparative study with separation by dextran.

Authors: M T Aguado; N Pujol; E Rubiol; M Tura; A Celada
Journal: J Immunol Methods Date: 1980 Impact factor: 2.303

6. Receptor-mediated uptake and degradation of 125I-chemotactic peptide by human neutrophils.

Authors: J Niedel; S Wilkinson; P Cuatrecasas
Journal: J Biol Chem Date: 1979-11-10 Impact factor: 5.157

7. Identification of beta-adrenergic receptors in human lymphocytes by (-) (3H) alprenolol binding.

Authors: L T Williams; R Snyderman; R J Lefkowitz
Journal: J Clin Invest Date: 1976-01 Impact factor: 14.808

8. Evidence for a noncholinergic site for nicotine's action in brain: psychopharmacological, electrophysiological and receptor binding studies.

Authors: L G Abood; K Lowy; A Tometsko; M MacNeil
Journal: Arch Int Pharmacodyn Ther Date: 1979-02

9. Altered oxidative metabolic responses in vitro of alveolar macrophages from asymptomatic cigarette smokers.

Authors: J R Hoidal; R B Fox; P A LeMarbe; R Perri; J E Repine
Journal: Am Rev Respir Dis Date: 1981-01

10. Relation of nicotine yield of cigarettes to blood nicotine concentrations in smokers.

Authors: M A Russell; M Jarvis; R Iyer; C Feyerabend
Journal: Br Med J Date: 1980-04-05

10 in total

1. Nicotine induces the expression of C-reactive protein via MAPK-dependent signal pathway in U937 macrophages.

Authors: Junjun Mao; Juntian Liu; Xiaoming Pang; Ming Li; Jinyan Song; Chunjie Han; Di Wu; Shuyue Wang
Journal: Mol Cells Date: 2012-11-06 Impact factor: 5.034

Review 2. CHRFAM7A, a human-specific and partially duplicated α7-nicotinic acetylcholine receptor gene with the potential to specify a human-specific inflammatory response to injury.

Authors: Todd W Costantini; Xitong Dang; Raul Coimbra; Brian P Eliceiri; Andrew Baird
Journal: J Leukoc Biol Date: 2014-12-03 Impact factor: 4.962

10. Neuronal stimulation with 5-hydroxytryptamine 4 receptor induces anti-inflammatory actions via α7nACh receptors on muscularis macrophages associated with postoperative ileus.

Authors: Yasuaki Tsuchida; Fumihiko Hatao; Masahiko Fujisawa; Takahisa Murata; Michio Kaminishi; Yasuyuki Seto; Masatoshi Hori; Hiroshi Ozaki
Journal: Gut Date: 2010-11-29 Impact factor: 23.059

10 in total

Evidence for a noncholinergic nicotine receptor on human phagocytic leukocytes.

1. Effect of tobacco smoking on the functions of polymorphonuclear leukocytes.

2. Demonstration that monocytes rather than lymphocytes are the insulin-binding cells in preparations of humah peripheral blood mononuclear leukocytes: implications for studies of insulin-resistant states in man.

3. Elastase release from human alveolar macrophages: comparison between smokers and nonsmokers.

4. Preservation of human granulocytes. II. Characteristics of granulocytes obtained by counterflow centrifugation.

5. Separation of granulocytes from peripheral blood in a single step using discontinuous density gradients of Ficoll-Urografin. A comparative study with separation by dextran.

6. Receptor-mediated uptake and degradation of 125I-chemotactic peptide by human neutrophils.

7. Identification of beta-adrenergic receptors in human lymphocytes by (-) (3H) alprenolol binding.

8. Evidence for a noncholinergic site for nicotine's action in brain: psychopharmacological, electrophysiological and receptor binding studies.

9. Altered oxidative metabolic responses in vitro of alveolar macrophages from asymptomatic cigarette smokers.

10. Relation of nicotine yield of cigarettes to blood nicotine concentrations in smokers.

1. Nicotine induces the expression of C-reactive protein via MAPK-dependent signal pathway in U937 macrophages.

Review 2. CHRFAM7A, a human-specific and partially duplicated α7-nicotinic acetylcholine receptor gene with the potential to specify a human-specific inflammatory response to injury.

Review 3. Alpha7 nicotinic receptors as novel therapeutic targets for inflammation-based diseases.

Review 4. Exploitation of the nicotinic anti-inflammatory pathway for the treatment of epithelial inflammatory diseases.

5. Mice lacking α4 nicotinic acetylcholine receptors are protected against alcohol-associated liver injury.

6. Evidence for an olfactory receptor which responds to nicotine--nicotine as an odorant.

7. Nicotinic acetylcholine receptors are sensors for ethanol in lung fibroblasts.

8. Nicotine-stimulated proteins in mouse cells are distinct from heat-shock proteins.

Review 9. The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation.

10. Neuronal stimulation with 5-hydroxytryptamine 4 receptor induces anti-inflammatory actions via α7nACh receptors on muscularis macrophages associated with postoperative ileus.