Minimal deviation adenocarcinoma of the uterine cervix has abnormal expression of sex steroid receptors, CA125, and gastric mucin.

To provide clues to the histological differentiation between minimal deviation adenocarcinoma (MDA) of the uterine cervix and normal cervical glands, we analyze the histochemical expression of ovarian steroid receptors [estrogen receptor (ER) and progesterone receptor (PR)], mucosubstances such as gastric mucin, CA125, and carcinoembryonic antigen (CEA) in normal cervical glands (10 cases) and MDA (seven cases). Mucin histochemistry showed that gastric mucin was focally demonstrated in all the cases of MDA but in none of the normal cervical glands. ER and PR were not expressed in MDA, whereas both receptors were invariably expressed in normal cervices. Expression of CA125 was significantly decreased in MDA, but was diffusely positive in normal endocervical glands. CEA was focally positive in all cases of MDA, but it was consistently negative in normal cervical glands. These results suggest that MDA lacks expression of the characteristic müllerian-type substances such as ER, PR, and CA125, and that a proportion of its cells contain gastric epithelial substances, comprising gastric mucin and CEA. In conclusion, loss of the expression of ER and PR, decreased expression of CA125, and staining for gastric mucin and CEA could be used for histologic discrimination of MDA from benign cervical glands.