| Literature DB >> 9099798 |
Abstract
Most rabbit B lymphocytes use the same VH gene in V(D)J gene rearrangements and undergo somatic diversification by gene conversion and hypermutation. Recent experiments have shown that V(D)J genes in essentially all rabbit B cells diversify shortly after birth and that this diversification occurs in the gut-associated lymphoid tissue. Still to be determined is whether this diversification is developmentally programmed or is driven by exogenous microbial antigens.Entities:
Mesh:
Year: 1997 PMID: 9099798 DOI: 10.1016/s0952-7915(97)80140-9
Source DB: PubMed Journal: Curr Opin Immunol ISSN: 0952-7915 Impact factor: 7.486