Literature DB >> 909780

Raman spectral studies of nucleic acids. XVII. Conformational structures of polyinosinic acid.

C H Chou, G J Thomas, S Arnott, P J Smith.   

Abstract

Laser-Raman spectra of poly(rI) show the formation of an ordered complex in aqueous solutions of high ionic strength. This structure exhibits the A-helix geometry, contains stacked bases and is apparently stabilized by specific hydrogen bonding involving hypoxanthine C6=0 groups. Thermal dissociation of the poly(rI) complex (Tm=45 degrees C) yields single-stranded and disordered poly (RI) chains. A disordered structure also occurs for poly (rI) in aqueous solutions of low ionic strength. In oriented films, poly (rI) forms an ordered structure probably the same as that which occurs in solutions of high ionic strength. Raman intensities measured at 815 and 1100 cm-1 in spectra of poly (rI) and poly (rU)-poly (rA)-poly(rU) indicate that the correlation previously established for single- and double-stranded ribopolymer structures is valid also for these multi-stranded structures. X-ray diffraction and model-building studies confirm the A-helix structure.

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Year:  1977        PMID： 909780      PMCID： PMC342574          DOI： 10.1093/nar/4.7.2407

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  15 in total

1.  Helix formation by guanylic acid.

Authors:  M GELLERT; M N LIPSETT; D R DAVIES
Journal:  Proc Natl Acad Sci U S A       Date:  1962-12-15       Impact factor: 11.205

2.  Tautomeric forms in a polynucleotide helix and their bearing on the structure of DNA.

Authors:  H T MILES
Journal:  Proc Natl Acad Sci U S A       Date:  1961-06-15       Impact factor: 11.205

3.  The molecular structure of polyinosinic acid.

Authors:  A RICH
Journal:  Biochim Biophys Acta       Date:  1958-09

4.  Kinetics of hydrogen-deuterium exchange in adenosine 5'-monophosphate, adenosine 3':5'-monophosphate, and poly(riboadenylic acid) determined by laser-Raman spectroscopy.

Authors:  G J Thomas; J Livramento
Journal:  Biochemistry       Date:  1975-11-18       Impact factor: 3.162

5.  Raman studies of nucleic acids. 8. Estimation of RNA secondary structure from Raman scattering by phosphate-group vibrations.

Authors:  G J Thomas; K A Hartman
Journal:  Biochim Biophys Acta       Date:  1973-06-23

6.  Raman studies of nucleic acids. XII. Conformations of oligonucleotides and deuterated polynucleotides.

Authors:  B Prescott; R Gamache; J Livramento; G J Thomas
Journal:  Biopolymers       Date:  1974       Impact factor: 2.505

7.  Structures for Poly(U)-poly(A)-poly(U)triple stranded polynucleotides.

Authors:  S Arnott; P J Bond
Journal:  Nat New Biol       Date:  1973-07-25

8.  The structures of polyinosinic acid.

Authors:  D Thiele; W Guschlbauer
Journal:  Biophysik       Date:  1973-05-30

9.  Structures for polyinosinic acid and polyguanylic acid.

Authors:  S Arnott; R Chandrasekaran; C M Marttila
Journal:  Biochem J       Date:  1974-08       Impact factor: 3.857

10.  Models of triple-stranded polynucleotides with optimised stereochemistry.

Authors:  S Arnott; P J Bond; E Selsing; P J Smith
Journal:  Nucleic Acids Res       Date:  1976-10       Impact factor: 16.971
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  4 in total

1.  G-DNA: a twice-folded DNA structure adopted by single-stranded oligo(dG) and its implications for telomeres.

Authors:  I G Panyutin; O I Kovalsky; E I Budowsky; R E Dickerson; M E Rikhirev; A A Lipanov
Journal:  Proc Natl Acad Sci U S A       Date:  1990-02       Impact factor: 11.205

2.  Raman spectral studies of poly(1-methylinosinic acid).

Authors:  W M Scovell; V Amarnath; A D Broom
Journal:  Nucleic Acids Res       Date:  1979-03       Impact factor: 16.971

3.  Poly(2-methylthio-7-deazainosinic acid)--hydrophobic stabilization of polynucleotide secondary structure by the 2-methylthio group.

Authors:  F Seela; J Ott; D Franzen
Journal:  Nucleic Acids Res       Date:  1983-09-10       Impact factor: 16.971

4.  Condensation of nucleic acids by intercalating aromatic cations.

Authors:  J Kapuscinski; Z Darzynkiewicz
Journal:  Proc Natl Acad Sci U S A       Date:  1984-12       Impact factor: 11.205
  4 in total

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