| Literature DB >> 9095625 |
K Kamada1, K Houkin, H Abe, Y Sawamura, T Kashiwaba.
Abstract
Proton magnetic resonance spectroscopy (1H MRS) was evaluated for distinguishing between radiation necrosis and recurrent glioma in 11 patients after high-dose radiotherapy. Six patients had a histological diagnosis of recurrent glioma. Four patients had a histological diagnosis of radiation necrosis and one had a clinical course consistent with the diagnosis of radiation necrosis. 1H MRS showed cases of radiation necrosis had two characteristic 1H MRS patterns: markedly increased lactate/creatine and phosphocreatine (Cr) ratio and decreased choline-containing compounds/Cr ratio compared to that of recurrent glioma; or all the major metabolites were completely diminished. The N-acetyl aspartate signal was not helpful for differential diagnosis. 1H MRS is a potentially useful method for differentiating tumor recurrence from radiation necrosis in patients treated for malignant glioma.Entities:
Mesh：
Year: 1997 PMID： 9095625 DOI： 10.2176/nmc.37.250
Source DB: PubMed Journal: Neurol Med Chir (Tokyo) ISSN： 0470-8105 Impact factor: 1.742