Literature DB >> 9089639

Presence of an acidic glycoprotein in the serum of arthritic rats: modulation by capsaicin and curcumin.

B Joe1, U J Rao, B R Lokesh.   

Abstract

Levels of various serum proteins were found to change in adjuvant induced arthritis. Increased levels of a glycoprotein with an apparent molecular weight of 72 kDa (Gp A72) were observed in the sera of arthritic rats. Gp A72 is an acidic glycoprotein with a pI of 5.1. Gp A72 also showed antitryptic activity. The appearance of Gp A72 in the serum preceded the onset of paw inflammation in arthritic rats and persisted in the chronic phase. Oral administration of the antiinflammatory spice principles-capsaicin (from red pepper) and curcumin (from turmeric) lowered the levels of Gp A72 by 88 and 73% respectively with concomitant lowering of paw inflammation in arthritic rats.

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Year:  1997        PMID： 9089639     DOI： 10.1023/a:1006877928703

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  30 in total

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Review 2.  Protons: small stimulants of capsaicin-sensitive sensory nerves.

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Journal:  Trends Neurosci       Date:  1994-12       Impact factor: 13.837

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Journal:  Mol Cell Biochem       Date:  1992-04       Impact factor: 3.396

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5.  A rapid, sensitive method for detection of alkaline phosphatase-conjugated anti-antibody on Western blots.

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Journal:  Anal Biochem       Date:  1984-01       Impact factor: 3.365

Review 6.  Mechanism of action of capsaicin-like molecules on sensory neurons.

Authors:  A Dray
Journal:  Life Sci       Date:  1992       Impact factor: 5.037

7.  Studies on the inhibitory effects of curcumin and eugenol on the formation of reactive oxygen species and the oxidation of ferrous iron.

Authors:  A C Reddy; B R Lokesh
Journal:  Mol Cell Biochem       Date:  1994-08-17       Impact factor: 3.396

8.  Limited effects of recombinant human and murine interleukin 1 and tumour necrosis factor on production of acute phase proteins by cultured rat hepatocytes.

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Journal:  Biochem Int       Date:  1987-03

9.  Inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice.

Authors:  M T Huang; Y R Lou; W Ma; H L Newmark; K R Reuhl; A H Conney
Journal:  Cancer Res       Date:  1994-11-15       Impact factor: 12.701

10.  Three high molecular weight protease inhibitors of rat plasma. Isolation, characterization, and acute phase changes.

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Journal:  J Biol Chem       Date:  1987-01-05       Impact factor: 5.157
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  20 in total

1.  Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis.

Authors:  Janet L Funk; Janice N Oyarzo; Jennifer B Frye; Guanjie Chen; R Clark Lantz; Shivanand D Jolad; Aniko M Sólyom; Barbara N Timmermann
Journal:  J Nat Prod       Date:  2006-03       Impact factor: 4.050

2.  Effect of curcumin and capsaicin on arachidonic acid metabolism and lysosomal enzyme secretion by rat peritoneal macrophages.

Authors:  B Joe; B R Lokesh
Journal:  Lipids       Date:  1997-11       Impact factor: 1.880

3.  Lipopolysaccharide fever is initiated via a capsaicin-sensitive mechanism independent of the subtype-1 vanilloid receptor.

Authors:  M Devrim Dogan; Shreya Patel; Alla Y Rudaya; Alexandre A Steiner; Miklós Székely; Andrej A Romanovsky
Journal:  Br J Pharmacol       Date:  2004-10-18       Impact factor: 8.739

4.  Potent anti-inflammatory effects of systemically administered curcumin modulate periodontal disease in vivo.

Authors:  M R Guimarães; L S Coimbra; S G de Aquino; L C Spolidorio; K L Kirkwood; C Rossa
Journal:  J Periodontal Res       Date:  2011-02-08       Impact factor: 4.419

Review 5.  Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases.

Authors:  Bharat B Aggarwal; Kuzhuvelil B Harikumar
Journal:  Int J Biochem Cell Biol       Date:  2008-07-09       Impact factor: 5.085

Review 6.  Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers.

Authors:  Bharat B Aggarwal; Subash C Gupta; Bokyung Sung
Journal:  Br J Pharmacol       Date:  2013-08       Impact factor: 8.739

7.  Oral administration of curcumin emulsified in carboxymethyl cellulose has a potent anti-inflammatory effect in the IL-10 gene-deficient mouse model of IBD.

Authors:  Victoria Y L Ung; Rae R Foshaug; Sarah M MacFarlane; Thomas A Churchill; Jason S G Doyle; Beate C Sydora; Richard N Fedorak
Journal:  Dig Dis Sci       Date:  2009-06-10       Impact factor: 3.199

8.  Curcumin ameliorates autoimmune diabetes. Evidence in accelerated murine models of type 1 diabetes.

Authors:  C N Castro; A E Barcala Tabarrozzi; J Winnewisser; M L Gimeno; M Antunica Noguerol; A C Liberman; D A Paz; R A Dewey; M J Perone
Journal:  Clin Exp Immunol       Date:  2014-07       Impact factor: 4.330

Review 9.  Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health.

Authors:  Ali Mobasheri; Yves Henrotin; Hans-Konrad Biesalski; Mehdi Shakibaei
Journal:  Int J Mol Sci       Date:  2012-03-30       Impact factor: 6.208

10.  Biological basis for the use of botanicals in osteoarthritis and rheumatoid arthritis: a review.

Authors:  Salahuddin Ahmed; Jeremy Anuntiyo; Charles J Malemud; Tariq M Haqqi
Journal:  Evid Based Complement Alternat Med       Date:  2005-09       Impact factor: 2.629
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