Literature DB >> 3496098

Limited effects of recombinant human and murine interleukin 1 and tumour necrosis factor on production of acute phase proteins by cultured rat hepatocytes.

A Koj, A Kurdowska, D Magielska-Zero, H Rokita, J D Sipe, J M Dayer, S Demczuk, J Gauldie.   

Abstract

Albumin, fibrinogen, alpha 1-acid glycoprotein and cysteine proteinase inhibitor were determined by electroimmunoassay in the media of primary cultures of rat hepatocytes exposed to dialysed supernatants of rat, mouse and human macrophages or to recombinant human and murine interleukin 1 and tumour necrosis factor. Recombinant cytokines in the range of 1 to 1000 ng/ml caused only reduction of albumin synthesis and slight stimulation of alpha 1 acid glycoprotein production while crude preparations of macrophage cytokines elicited typical acute phase response. The results suggest that interleukin 1 or tumour necrosis factor are not likely the principal mediators responsible for the direct stimulation of normal rat hepatocytes to acute phase protein synthesis.

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Year:  1987        PMID： 3496098

Source DB:  PubMed          Journal:  Biochem Int        ISSN： 0158-5231


  20 in total

Review 1.  Interleukin-6 and the acute phase response.

Authors:  P C Heinrich; J V Castell; T Andus
Journal:  Biochem J       Date:  1990-02-01       Impact factor: 3.857

2.  Presence of an acidic glycoprotein in the serum of arthritic rats: modulation by capsaicin and curcumin.

Authors:  B Joe; U J Rao; B R Lokesh
Journal:  Mol Cell Biochem       Date:  1997-04       Impact factor: 3.396

3.  Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells.

Authors:  J Gauldie; C Richards; D Harnish; P Lansdorp; H Baumann
Journal:  Proc Natl Acad Sci U S A       Date:  1987-10       Impact factor: 11.205

Review 4.  An alternative regulatory pathway of the acute phase response: the role of fibroblast-derived interferon-beta 2.

Authors:  A Koj; A H Gordon; J Gauldie
Journal:  Experientia       Date:  1988-01-15

Review 5.  Hepatic acute phase reaction in vivo and in vitro.

Authors:  H Baumann
Journal:  In Vitro Cell Dev Biol       Date:  1989-02

6.  Lack of effect of treatment with human recombinant-tumour necrosis factor (HrTNF) on the binding of quinidine to alpha 1-acid glycoprotein (AGP).

Authors:  J A Barnett; D E Brenner; P J Creaven; D Lalka
Journal:  Br J Clin Pharmacol       Date:  1989-02       Impact factor: 4.335

7.  Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis.

Authors:  P A Guerne; B L Zuraw; J H Vaughan; D A Carson; M Lotz
Journal:  J Clin Invest       Date:  1989-02       Impact factor: 14.808

8.  Effects of monocytic products, recombinant interleukin-1, and recombinant interleukin-6 on glycosylation of alpha 1-acid glycoprotein: studies with primary human hepatocyte cultures and rats.

Authors:  O Pos; H J Moshage; S H Yap; J P Snieders; L A Aarden; J van Gool; W Boers; A M Brugman; W van Dijk
Journal:  Inflammation       Date:  1989-08       Impact factor: 4.092

9.  IL-1 and IL-6 mediate increased production and synthesis by hepatocytes of acute-phase reactant mouse serum amyloid P-component (SAP).

Authors:  B F Lin; N O Ku; K Zahedi; A S Whitehead; R F Mortensen
Journal:  Inflammation       Date:  1990-06       Impact factor: 4.092

10.  Tumor necrosis factor-alpha inhibits albumin gene expression in a murine model of cachexia.

Authors:  D A Brenner; M Buck; S P Feitelberg; M Chojkier
Journal:  J Clin Invest       Date:  1990-01       Impact factor: 14.808
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