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Literature DB >> 9087506

In vitro and in vivo antichlamydial activities of HSR-903, a new fluoroquinolone antibiotic.

Y Niki¹, N Miyashita, Y Kubota, M Nakajima, T Matsushima.

Abstract

The in vitro and in vivo antichlamydial activities of HSR-903 were investigated. The MICs of HSR-903 for different species of chlamydia were 0.016 to 0.063 microg/ml, which were superior to those of conventional fluoroquinolones. The therapeutic effect of HSR-903 in experimental mouse Chlamydia psittaci pneumonia was also excellent and almost equal to that of minocycline and superior to that of ofloxacin. These results indicate that HSR-903 may be useful in the treatment of respiratory infections caused by chlamydiae.

Entities: Chemical Disease Species

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Year: 1997 PMID： 9087506 PMCID： PMC163811

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

5 in total

1. In vitro and in vivo activities of azithromycin, a new azalide antibiotic, against chlamydia.

Authors: Y Niki; M Kimura; N Miyashita; R Soejima
Journal: Antimicrob Agents Chemother Date: 1994-10 Impact factor: 5.191

2. The etiology of community-acquired pneumonia among hospitalized patients during a Chlamydia pneumoniae epidemic in Finland.

Authors: M T Kauppinen; E Herva; P Kujala; M Leinonen; P Saikku; H Syrjälä
Journal: J Infect Dis Date: 1995-11 Impact factor: 5.226

3. In vitro and in vivo antichlamydial activities of newly developed quinolone antimicrobial agents.

Authors: M Kimura; T Kishimoto; Y Niki; R Soejima
Journal: Antimicrob Agents Chemother Date: 1993-04 Impact factor: 5.191

4. In vitro activities of five quinolones against Chlamydia pneumoniae.

Authors: M R Hammerschlag; C L Hyman; P M Roblin
Journal: Antimicrob Agents Chemother Date: 1992-03 Impact factor: 5.191

Review 5. Current knowledge on Chlamydia pneumoniae, strain TWAR, an important cause of pneumonia and other acute respiratory diseases.

Authors: J T Grayston; S P Wang; C C Kuo; L A Campbell
Journal: Eur J Clin Microbiol Infect Dis Date: 1989-03 Impact factor: 3.267

5 in total

3 in total

In vitro and in vivo antichlamydial activities of HSR-903, a new fluoroquinolone antibiotic.

1. In vitro and in vivo activities of azithromycin, a new azalide antibiotic, against chlamydia.

2. The etiology of community-acquired pneumonia among hospitalized patients during a Chlamydia pneumoniae epidemic in Finland.

3. In vitro and in vivo antichlamydial activities of newly developed quinolone antimicrobial agents.

4. In vitro activities of five quinolones against Chlamydia pneumoniae.

Review 5. Current knowledge on Chlamydia pneumoniae, strain TWAR, an important cause of pneumonia and other acute respiratory diseases.

Review 1. Quinolones in sexually transmitted diseases: state of the art.

2. Effect of HSR-903, a new fluoroquinolone, on the concentration of theophylline in serum.

Review 3. Ofloxacin. A reappraisal of its use in the management of genitourinary tract infections.