Literature DB >> 12937001

Effects of Ser130Gly and Asp240Lys substitutions in extended-spectrum beta-lactamase CTX-M-9.

C Aumeran1, C Chanal, R Labia, D Sirot, J Sirot, R Bonnet.   

Abstract

In CTX-M-9 extended-spectrum beta-lactamases (ESBLs), an S130G mutation induced a 40- to 650-fold increase in 50% inhibitory concentrations but decreased hydrolytic activity against cefotaxime. A D240K mutation did not modify enzymatic efficiency against ceftazidime. Residue K240 could interact with Q270 and therefore not with ceftazidime, in contrast with what was observed with certain TEM/SHV-type ESBLs.

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Year:  2003        PMID： 12937001      PMCID： PMC182627          DOI： 10.1128/AAC.47.9.2958-2961.2003

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

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Authors:  C Neuwirth; S Madec; E Siebor; A Pechinot; J M Duez; M Pruneaux; M Fouchereau-Peron; A Kazmierczak; R Labia
Journal:  Antimicrob Agents Chemother       Date:  2001-12       Impact factor: 5.191

2.  Plasmid-mediated extended-spectrum beta-lactamase (CTX-M-3 like) from India and gene association with insertion sequence ISEcp1.

Authors:  A Karim; L Poirel; S Nagarajan; P Nordmann
Journal:  FEMS Microbiol Lett       Date:  2001-07-24       Impact factor: 2.742

3.  A novel CTX-M beta-lactamase (CTX-M-8) in cefotaxime-resistant Enterobacteriaceae isolated in Brazil.

Authors:  R Bonnet; J L Sampaio; R Labia; C De Champs; D Sirot; C Chanal; J Sirot
Journal:  Antimicrob Agents Chemother       Date:  2000-07       Impact factor: 5.191

4.  Molecular characterization of TEM-59 (IRT-17), a novel inhibitor-resistant TEM-derived beta-lactamase in a clinical isolate of Klebsiella oxytoca.

Authors:  H Bermudes; F Jude; E B Chaibi; C Arpin; C Bebear; R Labia; C Quentin
Journal:  Antimicrob Agents Chemother       Date:  1999-07       Impact factor: 5.191

5.  Computerized microacidimetric determination of beta lactamase Michaelis-Menten constants.

Authors:  R Labia; J Andrillon; F Le Goffic
Journal:  FEBS Lett       Date:  1973-06-15       Impact factor: 4.124

6.  An ultrahigh resolution structure of TEM-1 beta-lactamase suggests a role for Glu166 as the general base in acylation.

Authors:  George Minasov; Xiaojun Wang; Brian K Shoichet
Journal:  J Am Chem Soc       Date:  2002-05-15       Impact factor: 15.419

7.  Novel cefotaximase (CTX-M-16) with increased catalytic efficiency due to substitution Asp-240-->Gly.

Authors:  R Bonnet; C Dutour; J L Sampaio; C Chanal; D Sirot; R Labia; C De Champs; J Sirot
Journal:  Antimicrob Agents Chemother       Date:  2001-08       Impact factor: 5.191

8.  CTX-M-type extended-spectrum beta-lactamase that hydrolyzes ceftazidime through a single amino acid substitution in the omega loop.

Authors:  L Poirel; T Naas; I Le Thomas; A Karim; E Bingen; P Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2001-12       Impact factor: 5.191

9.  Acyl-intermediate structures of the extended-spectrum class A beta-lactamase, Toho-1, in complex with cefotaxime, cephalothin, and benzylpenicillin.

Authors:  Tatsuro Shimamura; Akiko Ibuka; Shinya Fushinobu; Takayoshi Wakagi; Masaji Ishiguro; Yoshikazu Ishii; Hiroshi Matsuzawa
Journal:  J Biol Chem       Date:  2002-09-08       Impact factor: 5.157

10.  Ceftazidime-hydrolysing CTX-M-15 extended-spectrum beta-lactamase (ESBL) in Poland.

Authors:  Anna Baraniak; Janusz Fiett; Waleria Hryniewicz; Patrice Nordmann; Marek Gniadkowski
Journal:  J Antimicrob Chemother       Date:  2002-09       Impact factor: 5.790
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  9 in total

1.  Molecular and kinetic comparison of the novel extended-spectrum beta-lactamases CTX-M-25 and CTX-M-26.

Authors:  Craig J Munday; David A Boyd; Nigel Brenwald; Mark Miller; Jennifer M Andrews; Richard Wise; Michael R Mulvey; Peter M Hawkey
Journal:  Antimicrob Agents Chemother       Date:  2004-12       Impact factor: 5.191

2.  Distant and new mutations in CTX-M-1 beta-lactamase affect cefotaxime hydrolysis.

Authors:  Francisco José Pérez-Llarena; Frédéric Kerff; Olga Abián; Susana Mallo; María Carmen Fernández; Moreno Galleni; Javier Sancho; Germán Bou
Journal:  Antimicrob Agents Chemother       Date:  2011-07-05       Impact factor: 5.191

3.  In vitro selection of variants resistant to beta-lactams plus beta-lactamase inhibitors in CTX-M beta-lactamases: predicting the in vivo scenario?

Authors:  Aida Ripoll; Fernando Baquero; Angela Novais; Mario J Rodríguez-Domínguez; Maria-Carmen Turrientes; Rafael Cantón; Juan-Carlos Galán
Journal:  Antimicrob Agents Chemother       Date:  2011-07-25       Impact factor: 5.191

4.  Excess positional mutual information predicts both local and allosteric mutations affecting beta lactamase drug resistance.

Authors:  George A Cortina; Peter M Kasson
Journal:  Bioinformatics       Date:  2016-07-27       Impact factor: 6.937

5.  Structural consequences of the inhibitor-resistant Ser130Gly substitution in TEM beta-lactamase.

Authors:  Veena L Thomas; Dasantila Golemi-Kotra; Choonkeun Kim; Sergei B Vakulenko; Shahriar Mobashery; Brian K Shoichet
Journal:  Biochemistry       Date:  2005-07-05       Impact factor: 3.162

6.  The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition.

Authors:  Nuno Mendonça; Vera Manageiro; Frédéric Robin; M José Salgado; Eugénia Ferreira; Manuela Caniça; Richard Bonnet
Journal:  Antimicrob Agents Chemother       Date:  2008-03-03       Impact factor: 5.191

7.  CTX-M Enzymes: Origin and Diffusion.

Authors:  Rafael Cantón; José María González-Alba; Juan Carlos Galán
Journal:  Front Microbiol       Date:  2012-04-02       Impact factor: 5.640

8.  Insight into the effect of inhibitor resistant S130G mutant on physico-chemical properties of SHV type beta-lactamase: a molecular dynamics study.

Authors:  Mohd Hassan Baig; D Raja Sudhakar; Ponnusamy Kalaiarasan; Naidu Subbarao; Gulshan Wadhawa; Mohtashim Lohani; M Kalim A Khan; Asad U Khan
Journal:  PLoS One       Date:  2014-12-05       Impact factor: 3.240

9.  Predicting allosteric mutants that increase activity of a major antibiotic resistance enzyme.

Authors:  M J Latallo; G A Cortina; S Faham; R K Nakamoto; P M Kasson
Journal:  Chem Sci       Date:  2017-07-19       Impact factor: 9.825
  9 in total

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