| Literature DB >> 9086517 |
Abstract
Maternal serum analyte screening is an integral component of contemporary antenatal care. Based on elevated MSAFP levels, 85% to 90% of NTDs (e.g., anencephaly or spina bifida) can be detected. Using a combination of serum analytes (e.g., MSAFP, hCG, UE3) 55% to 60% of fetal Down's syndrome can be detected. Future strategies for Down's syndrome screening may include the use of new markers such as dimeric inhibin-A and urinary beta-core fragment of hCG, as well as first-trimester screening, particularly with PAPP-A and free beta-hCG.Entities:
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Year: 1997 PMID: 9086517 DOI: 10.1016/s0889-8545(05)70288-6
Source DB: PubMed Journal: Obstet Gynecol Clin North Am ISSN: 0889-8545 Impact factor: 2.844