| Literature DB >> 9084760 |
Abstract
The catabolite repressor-activator (Cra) protein controls the direction of carbon flux through metabolic pathways in enteric bacteria. Cra binds to the control regions of target genes and exerts a negative effect on the expression of genes encoding glycolytic and Entner-Doudoroff enzymes, while exerting a positive effect on genes encoding Krebs cycle, glyoxylate shunt and gluconeogenic enzymes. Cra mediates cyclic AMP-independent catabolite repression of positively Cra-regulated genes and catabolite activation of negatively Cra-controlled genes.Entities:
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Year: 1996 PMID: 9084760 DOI: 10.1016/0923-2508(96)84003-4
Source DB: PubMed Journal: Res Microbiol ISSN: 0923-2508 Impact factor: 3.992