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Literature DB >> 9081234

A Dutch population study of the STR loci D21S11 and HUMFIBRA.

A Ovington¹, P Daselaar, M Sjerps, A Kloosterman.

Abstract

To introduce a duplex PCR system consisting of the STR loci D21S11 and HUMFIBRA in forensic identity testing we analysed a Dutch Caucasian database of 205 individuals. The combined power of discrimination of the two loci is 0.9978 and there was no evidence for linkage equilibrium between the two loci (p = 0.91). However, we noticed departure from Hardy-Weinberg equilibrium for the D21S11-locus in our database (p = 0.03), but the differences between observed and expected D21S11 allele pair frequencies were of negligible practical significance in forensic calculations.

Entities: Gene

Mesh：

Substances：
Genetic Markers

Year: 1997 PMID： 9081234 DOI： 10.1007/bf02441019

Source DB: PubMed Journal: Int J Legal Med ISSN： 0937-9827 Impact factor: 2.686

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References

13 in total

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Authors: M D Barber; B J McKeown; B H Parkin
Journal: Int J Legal Med Date: 1996 Impact factor: 2.686

2. Tetranucleotide repeat polymorphism at the D21S11 locus.

Authors: V Sharma; M Litt
Journal: Hum Mol Genet Date: 1992-04 Impact factor: 6.150

3. Tetranucleotide repeat polymorphism at the human alpha fibrinogen locus (FGA).

Authors: K A Mills; D Even; J C Murray
Journal: Hum Mol Genet Date: 1992-12 Impact factor: 6.150

4. A Dutch population study of the STR Loci HUMTHO1, HUMFES/FPS, HUMVWA31/1 and HUMF13A1, conducted for forensic purposes.

Authors: M Sjerps; N van der Geest; C Pieron; M Gajadhar; A Kloosterman
Journal: Int J Legal Med Date: 1995 Impact factor: 2.686

A Dutch population study of the STR loci D21S11 and HUMFIBRA.

1. Structural variation in the alleles of a short tandem repeat system at the human alpha fibrinogen locus.

2. Tetranucleotide repeat polymorphism at the D21S11 locus.

3. Tetranucleotide repeat polymorphism at the human alpha fibrinogen locus (FGA).

4. A Dutch population study of the STR Loci HUMTHO1, HUMFES/FPS, HUMVWA31/1 and HUMF13A1, conducted for forensic purposes.

5. Estimating minimum allele frequencies for DNA profile frequency estimates for PCR-based loci.

6. Establishing the robustness of short-tandem-repeat statistics for forensic applications.

7. The validation of short tandem repeat (STR) loci for use in forensic casework.

8. Highly discriminating heptaplex short tandem repeat PCR system for forensic identification.

9. Evaluation of an automated DNA profiling system employing multiplex amplification of four tetrameric STR loci.

10. Different types of structural variation in STRs: HumFES/FPS, HumVWA and HumD21S11.