Literature DB >> 9080871

Population structure of Plasmodium falciparum in villages with different malaria endemicity in east Africa.

H A Babiker1, J Lines, W G Hill, D Walliker.   

Abstract

We have compared allelic polymorphism of two merozoite surface protein genes, MSP-1 and MSP-2, of Plasmodium falciparum and the parasite load in infected individuals in two villages in east Africa. In Michenga village in Tanzania, malaria is holoendemic and transmission is perennial; in Asar village in Sudan, malaria is mesoendemic and transmission is markedly seasonal. The numbers of alleles of both genes were found to be much greater in Michenga than in Asar. More parasite clones exhibiting higher allelic polymorphisms of the genes studied were carried by infected inhabitants in Michenga than those in Asar. The high mean number of clones in Michenga is associated with a very high frequency of out-crossing compared with that estimated in Asar.

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Year:  1997        PMID： 9080871     DOI： 10.4269/ajtmh.1997.56.141

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN： 0002-9637            Impact factor:   2.345


  49 in total

1.  Analysis of polymorphisms in the merozoite surface protein-3α gene and two microsatellite loci in Sri Lankan Plasmodium vivax: evidence of population substructure in Sri Lanka.

Authors:  Mette L Schousboe; Rupika S Rajakaruna; Priyanie H Amerasinghe; Flemming Konradsen; Rosalynn Ord; Richard Pearce; Ib C Bygbjerg; Cally Roper; Michael Alifrangis
Journal:  Am J Trop Med Hyg       Date:  2011-12       Impact factor: 2.345

2.  Genetic diversity in the Block 2 region of the merozoite surface protein 1 (MSP-1) of Plasmodium falciparum: additional complexity and selection and convergence in fragment size polymorphism.

Authors:  S L Takala; A A Escalante; O H Branch; S Kariuki; S Biswas; S C Chaiyaroj; A A Lal
Journal:  Infect Genet Evol       Date:  2006-03-06       Impact factor: 3.342

3.  Allelic diversity and naturally acquired allele-specific antibody responses to Plasmodium falciparum apical membrane antigen 1 in Kenya.

Authors:  Faith H A Osier; Gareth D Weedall; Federica Verra; Linda Murungi; Kevin K A Tetteh; Pete Bull; Bart W Faber; Ed Remarque; Alan Thomas; Kevin Marsh; David J Conway
Journal:  Infect Immun       Date:  2010-08-23       Impact factor: 3.441

4.  Allelic polymorphism of MSP2 gene in severe P. falciparum malaria in an area of low and seasonal transmission.

Authors:  Ishraga E A-Elbasit; Gehad ElGhazali; Thoraya M E A-Elgadir; Amel A Hamad; Hamza A Babiker; Mustafa I Elbashir; Hayder A Giha
Journal:  Parasitol Res       Date:  2007-09-04       Impact factor: 2.289

5.  Genetic diversity of Plasmodium falciparum field isolates from south western Nigeria.

Authors:  G I Olasehinde; C S Yah; R Singh; O Olusola Ojuronbge; A A Ajayi; N Valecha; A O Abolaji; A O Adeyeba
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6.  Transmission-dependent tolerance to multiclonal Plasmodium falciparum infection.

Authors:  Anna Färnert; Thomas N Williams; Tabitha W Mwangi; Anna Ehlin; Greg Fegan; Alex Macharia; Brett S Lowe; Scott M Montgomery; Kevin Marsh
Journal:  J Infect Dis       Date:  2009-10-01       Impact factor: 5.226

7.  Complexity and genetic diversity of Plasmodium falciparum infections in young children living in urban areas of Central and West Africa.

Authors:  Saadou Issifou; Christophe Rogier; Marius Adjagba-Olakpo; Nicodème Chabi-Worou; Francine Ntoumi
Journal:  Parasitol Res       Date:  2003-05-21       Impact factor: 2.289

8.  Analysis of genetic polymorphism in select vaccine candidate antigens and microsatellite loci in Plasmodium falciparum from endemic areas at varying altitudes.

Authors:  Godfree Mlambo; David Sullivan; Susan L Mutambu; White Soko; Joel Mbedzi; James Chivenga; Thomas Jaenisch; Armin Gemperli; Nirbhay Kumar
Journal:  Acta Trop       Date:  2007-05-22       Impact factor: 3.112

9.  Comparison of Plasmodium falciparum allelic frequency distribution in different endemic settings by high-resolution genotyping.

Authors:  Sonja Schoepflin; Francesca Valsangiacomo; Enmoore Lin; Benson Kiniboro; Ivo Mueller; Ingrid Felger
Journal:  Malar J       Date:  2009-10-30       Impact factor: 2.979

10.  Genetic diversity among Plasmodium falciparum field isolates in Pakistan measured with PCR genotyping of the merozoite surface protein 1 and 2.

Authors:  Najia K Ghanchi; Andreas Mårtensson; Johan Ursing; Sana Jafri; Sándor Bereczky; Rabia Hussain; Mohammad A Beg
Journal:  Malar J       Date:  2010-01-01       Impact factor: 2.979
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