Literature DB >> 9074891

Can trifluoperazine protect mitochondria against reactive oxygen species-induced damage?

R de D Pereira1, M Hermes-Lima.   

Abstract

Trifluoperazine (TFP) (35 microM) prevents mitochondrial transmembrane potential (delta psi) collapse and swelling induced by 10 microM Ca2+ plus oxyradicals generated from delta-aminolevulinic acid autoxidation. In contrast with EGTA, TFP cannot restore the totally collapsed delta psi. So, TFP might not remove Ca2+ from its 'harmful site', but could impair the ROS-driven cross-linking between membrane-SH proteins. Our data are correlated with the protective uses of TFP against oxidative processes promoted by oxyradicals plus Ca2+.

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Year:  1996        PMID： 9074891     DOI： 10.1007/BF03189728

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  16 in total

1.  Protective effect of trifluoperazine on the mitochondrial damage induced by Ca2+ plus prooxidants.

Authors:  R S Pereira; A P Bertocchi; A E Vercesi
Journal:  Biochem Pharmacol       Date:  1992-11-03       Impact factor: 5.858

Review 2.  Role of Ca2+ in toxic cell killing.

Authors:  S Orrenius; D J McConkey; G Bellomo; P Nicotera
Journal:  Trends Pharmacol Sci       Date:  1989-07       Impact factor: 14.819

3.  Comparison of the effect of cyclosporine, verapamil, and trifluoperazine on calcium-induced membrane permeability of mitochondria.

Authors:  T Strzelecki; B R McGraw; R B Khauli
Journal:  Transplant Proc       Date:  1989-02       Impact factor: 1.066

4.  Evidence for an early free radical-mediated reperfusion injury in frostbite.

Authors:  P N Manson; R Jesudass; L Marzella; G B Bulkley; M J Im; K K Narayan
Journal:  Free Radic Biol Med       Date:  1991       Impact factor: 7.376

5.  The participation of reactive oxygen species and protein thiols in the mechanism of mitochondrial inner membrane permeabilization by calcium plus prooxidants.

Authors:  V G Valle; M M Fagian; L S Parentoni; A R Meinicke; A E Vercesi
Journal:  Arch Biochem Biophys       Date:  1993-11-15       Impact factor: 4.013

6.  Effects of calmodulin antagonists on the active Ca2+ uptake by rat liver mitochondria.

Authors:  M G Vale; A J Moreno; A P Carvalho
Journal:  Biochem J       Date:  1983-09-15       Impact factor: 3.857

7.  Membrane potential of mitochondria measured with an electrode sensitive to tetraphenyl phosphonium and relationship between proton electrochemical potential and phosphorylation potential in steady state.

Authors:  N Kamo; M Muratsugu; R Hongoh; Y Kobatake
Journal:  J Membr Biol       Date:  1979-08       Impact factor: 1.843

8.  Membrane protein thiol cross-linking associated with the permeabilization of the inner mitochondrial membrane by Ca2+ plus prooxidants.

Authors:  M M Fagian; L Pereira-da-Silva; I S Martins; A E Vercesi
Journal:  J Biol Chem       Date:  1990-11-15       Impact factor: 5.157

9.  Catabolism of 5-aminolevulinic acid to CO2 by rat liver mitochondria.

Authors:  M H Medeiros; P Di Mascio; S Gründel; S Soboll; H Sies; E J Bechara
Journal:  Arch Biochem Biophys       Date:  1994-04       Impact factor: 4.013

10.  Calcium-dependent mitochondrial oxidative damage promoted by 5-aminolevulinic acid.

Authors:  M Hermes-Lima; R F Castilho; V G Valle; E J Bechara; A E Vercesi
Journal:  Biochim Biophys Acta       Date:  1992-12-10
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  2 in total

1.  The use of calcium blockers to study biochemical behaviour of Saccharomyces cerevisiae cells.

Authors:  R de Souza Pereira
Journal:  Mol Cell Biochem       Date:  2001-12       Impact factor: 3.396

2.  Direct observation of oxidative stress on the cell wall of Saccharomyces cerevisiae strains with atomic force microscopy.

Authors:  R de Souza Pereira; J Geibel
Journal:  Mol Cell Biochem       Date:  1999-11       Impact factor: 3.396
  2 in total

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