| Literature DB >> 2672472 |
S Orrenius, D J McConkey, G Bellomo, P Nicotera.
Abstract
Recent work has shown that a sustained increase in cytosolic Ca2+ concentration is often linked to the onset of cytotoxicity. Sten Orrenius and colleagues describe several biochemical mechanisms that are stimulated by such a Ca2+ increase and can directly mediate cell death by causing disruption of the cytoskeleton, DNA fragmentation and extensive damage to other cell components.Entities:
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Year: 1989 PMID： 2672472 DOI： 10.1016/0165-6147(89)90029-1
Source DB: PubMed Journal: Trends Pharmacol Sci ISSN： 0165-6147 Impact factor: 14.819