Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Identification of a novel antiapoptotic protein, GAM-1, encoded by the CELO adenovirus.

Literature DB >> 9060680

Identification of a novel antiapoptotic protein, GAM-1, encoded by the CELO adenovirus.

Abstract

We have developed a simple screening method to identify genes that mimic bcl-2 or adenovirus E1B 19K in enhancing cell survival after transfection and have used this method to identify such a gene in the avian adenovirus CELO. The gene encodes a novel 30-kDa nuclear protein, which we have named GAM-1, that functions comparably to Bcl-2 and adenovirus E1B 19K in blocking apoptosis. However, GAM-1 has no sequence homology to Bcl-2, E1B 19K, or any other known antiapoptotic proteins and thus defines a novel antiapoptotic function.

Entities: Species

Mesh：

Substances：

Year: 1997 PMID： 9060680 PMCID： PMC191449

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

69 in total

1. Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death.

Authors: S Henderson; M Rowe; C Gregory; D Croom-Carter; F Wang; R Longnecker; E Kieff; A Rickinson
Journal: Cell Date: 1991-06-28 Impact factor: 41.582

2. Adenovirus E1B 19-kilodalton protein overcomes the cytotoxicity of E1A proteins.

Authors: E White; R Cipriani; P Sabbatini; A Denton
Journal: J Virol Date: 1991-06 Impact factor: 5.103

3. DNA-binding transferrin conjugates as functional gene-delivery agents: synthesis by linkage of polylysine or ethidium homodimer to the transferrin carbohydrate moiety.

Authors: E Wagner; M Cotten; K Mechtler; H Kirlappos; M L Birnstiel
Journal: Bioconjug Chem Date: 1991 Jul-Aug Impact factor: 4.774

4. A peptide sequence from Bax that converts Bcl-2 into an activator of apoptosis.

Authors: J J Hunter; T G Parslow
Journal: J Biol Chem Date: 1996-04-12 Impact factor: 5.157

5. Functional dissection of the human Bcl2 protein: sequence requirements for inhibition of apoptosis.

Authors: J J Hunter; B L Bond; T G Parslow
Journal: Mol Cell Biol Date: 1996-03 Impact factor: 4.272

6. The complete DNA sequence and genomic organization of the avian adenovirus CELO.

Authors: S Chiocca; R Kurzbauer; G Schaffner; A Baker; V Mautner; M Cotten
Journal: J Virol Date: 1996-05 Impact factor: 5.103

7. Hormone-dependent transcriptional regulation and cellular transformation by Fos-steroid receptor fusion proteins.

Authors: G Superti-Furga; G Bergers; D Picard; M Busslinger
Journal: Proc Natl Acad Sci U S A Date: 1991-06-15 Impact factor: 11.205

8. The dual effect of adenovirus type 5 E1A 13S protein on NF-kappaB activation is antagonized by E1B 19K.

Authors: M L Schmitz; A Indorf; F P Limbourg; H Städtler; E B Traenckner; P A Baeuerle
Journal: Mol Cell Biol Date: 1996-08 Impact factor: 4.272

9. Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis.

Authors: S Grimm; M K Bauer; P A Baeuerle; K Schulze-Osthoff
Journal: J Cell Biol Date: 1996-07 Impact factor: 10.539

10. The 19-kilodalton adenovirus E1B transforming protein inhibits programmed cell death and prevents cytolysis by tumor necrosis factor alpha.

Authors: E White; P Sabbatini; M Debbas; W S Wold; D I Kusher; L R Gooding
Journal: Mol Cell Biol Date: 1992-06 Impact factor: 4.272

19 in total

1. Adenovirus E3-6.7K maintains calcium homeostasis and prevents apoptosis and arachidonic acid release.

Authors: Alexander R Moise; Jason R Grant; Timothy Z Vitalis; Wilfred A Jefferies
Journal: J Virol Date: 2002-02 Impact factor: 5.103

Review 2. Human pathogens and the host cell SUMOylation system.

Authors: Peter Wimmer; Sabrina Schreiner; Thomas Dobner
Journal: J Virol Date: 2011-11-09 Impact factor: 5.103

3. SUMOylation mediates CtIP's functions in DNA end resection and replication fork protection.

Authors: Andrew J Locke; Lazina Hossain; Glynnis McCrostie; Daryl A Ronato; Amira Fitieh; Tanzeem Ahmed Rafique; Fatemeh Mashayekhi; Mobina Motamedi; Jean-Yves Masson; Ismail Hassan Ismail
Journal: Nucleic Acids Res Date: 2021-01-25 Impact factor: 16.971

Identification of a novel antiapoptotic protein, GAM-1, encoded by the CELO adenovirus.

1. Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death.

2. Adenovirus E1B 19-kilodalton protein overcomes the cytotoxicity of E1A proteins.

3. DNA-binding transferrin conjugates as functional gene-delivery agents: synthesis by linkage of polylysine or ethidium homodimer to the transferrin carbohydrate moiety.

4. A peptide sequence from Bax that converts Bcl-2 into an activator of apoptosis.

5. Functional dissection of the human Bcl2 protein: sequence requirements for inhibition of apoptosis.

6. The complete DNA sequence and genomic organization of the avian adenovirus CELO.

7. Hormone-dependent transcriptional regulation and cellular transformation by Fos-steroid receptor fusion proteins.

8. The dual effect of adenovirus type 5 E1A 13S protein on NF-kappaB activation is antagonized by E1B 19K.

9. Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis.

10. The 19-kilodalton adenovirus E1B transforming protein inhibits programmed cell death and prevents cytolysis by tumor necrosis factor alpha.

1. Adenovirus E3-6.7K maintains calcium homeostasis and prevents apoptosis and arachidonic acid release.

Review 2. Human pathogens and the host cell SUMOylation system.

3. SUMOylation mediates CtIP's functions in DNA end resection and replication fork protection.

4. Characterization of a new species of adenovirus in falcons.

5. Expression and in vitro functional analyses of recombinant Gam1 protein.

6. Characterization of CELO virus proteins that modulate the pRb/E2F pathway.

7. Construction of avian adenovirus CELO recombinants in cosmids.

8. Mutational analysis of the avian adenovirus CELO, which provides a basis for gene delivery vectors.

9. Transcriptional organization of the avian adenovirus CELO.

10. The adenovirus protein Gam1 interferes with sumoylation of histone deacetylase 1.