Literature DB >> 9057422

Intravenous alpha-1-antitrypsin replacement therapy: case report after one year of treatment.

A C Ward1, B A Keogh.   

Abstract

Alpha-1-antitrypsin deficiency is an autosomally inherited disease in which individuals homozygous for the disorder are prone to develop severe emphysema. We report the case of a 43 yr old man with severe deficiency and advanced emphysema and the first experience in Ireland with intravenous alpha-1-antitrypsin replacement. After 1 yr of replacement therapy we report our experience with dosage and frequency of infusion as well as pulmonary function test data before and during treatment.

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Year:  1997        PMID： 9057422     DOI： 10.1007/bf02939766

Source DB:  PubMed          Journal:  Ir J Med Sci        ISSN： 0021-1265            Impact factor:   1.568


  9 in total

Review 1.  Guidelines for the approach to the patient with severe hereditary alpha-1-antitrypsin deficiency. American Thoracic Society.

Authors: 
Journal:  Am Rev Respir Dis       Date:  1989-11

Review 2.  Alpha 1-antitrypsin deficiency, emphysema, and liver disease. Genetic basis and strategies for therapy.

Authors:  R G Crystal
Journal:  J Clin Invest       Date:  1990-05       Impact factor: 14.808

3.  Alpha 1-antitrypsin deficiency--diagnosis, treatment, and control: identification of patients.

Authors:  A S Buist
Journal:  Lung       Date:  1990       Impact factor: 2.584

4.  Replacement therapy for alpha 1-antitrypsin deficiency associated with emphysema.

Authors:  M D Wewers; M A Casolaro; S E Sellers; S C Swayze; K M McPhaul; J T Wittes; R G Crystal
Journal:  N Engl J Med       Date:  1987-04-23       Impact factor: 91.245

5.  Clinical features and history of the destructive lung disease associated with alpha-1-antitrypsin deficiency of adults with pulmonary symptoms.

Authors:  M L Brantly; L D Paul; B H Miller; R T Falk; M Wu; R G Crystal
Journal:  Am Rev Respir Dis       Date:  1988-08

6.  Biochemical efficacy and safety of monthly augmentation therapy for alpha 1-antitrypsin deficiency.

Authors:  R C Hubbard; S Sellers; D Czerski; L Stephens; R G Crystal
Journal:  JAMA       Date:  1988-09-02       Impact factor: 56.272

7.  Replacement therapy for hereditary alpha1-antitrypsin deficiency. A program for long-term administration.

Authors:  A F Barker; F Siemsen; D Pasley; R D'Silva; A S Buist
Journal:  Chest       Date:  1994-05       Impact factor: 9.410

Review 8.  Alpha-1-antitrypsin augmentation therapy for alpha-1-antitrypsin deficiency.

Authors:  R C Hubbard; R G Crystal
Journal:  Am J Med       Date:  1988-06-24       Impact factor: 4.965

9.  Recombinant DNA-produced alpha 1-antitrypsin administered by aerosol augments lower respiratory tract antineutrophil elastase defenses in individuals with alpha 1-antitrypsin deficiency.

Authors:  R C Hubbard; N G McElvaney; S E Sellers; J T Healy; D B Czerski; R G Crystal
Journal:  J Clin Invest       Date:  1989-10       Impact factor: 14.808
  9 in total

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