Literature DB >> 9056723

PAX-6 in development and evolution.

P Callaerts1, G Halder, W J Gehring.   

Abstract

Pax-6 is a member of the Pax gene class and encodes a protein containing a paired domain and a homeodomain. The molecular characterization of Pax-6 genes from species of different animal phyla and the analysis of Pax-6 function in the developing eyes and central nervous system of vertebrates, Drosophila melanogaster, and Caenorhabditis elegans suggest that Pax-6 homologues share conserved functions. In this review, we present recent data on the structural and functional characterization of Pax-6 homologues from species of different animal phyla. We discuss the implications of these findings for our understanding of the development and evolution of eyes and nervous systems.

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Year:  1997        PMID： 9056723     DOI： 10.1146/annurev.neuro.20.1.483

Source DB:  PubMed          Journal:  Annu Rev Neurosci        ISSN： 0147-006X            Impact factor:   12.449


  105 in total

1.  Notch signaling and the determination of appendage identity.

Authors:  S Kurata; M J Go; S Artavanis-Tsakonas; W J Gehring
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-29       Impact factor: 11.205

2.  Expression of evolutionarily conserved eye specification genes during Drosophila embryogenesis.

Authors:  J P Kumar; K Moses
Journal:  Dev Genes Evol       Date:  2001-09       Impact factor: 0.900

3.  Brakes and gas pedals. Meeting: Spetses 2000, molecular mechanisms of development and disease.

Authors:  C R Clapier; J de Boer ; M E Pacold; R Tamme; L C van Dinten
Journal:  EMBO Rep       Date:  2001-07       Impact factor: 8.807

4.  Conservation of Pax 6 function and upstream activation by Notch signaling in eye development of frogs and flies.

Authors:  Yasuko Onuma; Shuji Takahashi; Makoto Asashima; Shoichiro Kurata; Walter J Gehring
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-12       Impact factor: 11.205

Review 5.  Developmental genetic evidence for a monophyletic origin of the bilaterian brain.

Authors:  H Reichert; A Simeone
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2001-10-29       Impact factor: 6.237

6.  Defect of tyrosine hydroxylase-immunoreactive neurons in the brains of mice lacking the transcription factor Pax6.

Authors:  T Vitalis; O Cases; D Engelkamp; C Verney; D J Price
Journal:  J Neurosci       Date:  2000-09-01       Impact factor: 6.167

7.  CnidBase: The Cnidarian Evolutionary Genomics Database.

Authors:  Joseph F Ryan; John R Finnerty
Journal:  Nucleic Acids Res       Date:  2003-01-01       Impact factor: 16.971

8.  The PAX6 gene is activated by the basic helix-loop-helix transcription factor NeuroD/BETA2.

Authors:  Eleonora Marsich; Amedeo Vetere; Matteo Di Piazza; Gianluca Tell; Sergio Paoletti
Journal:  Biochem J       Date:  2003-12-15       Impact factor: 3.857

9.  Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function.

Authors:  Yvan Gosmain; Eric Marthinet; Claire Cheyssac; Audrey Guérardel; Aline Mamin; Liora S Katz; Karim Bouzakri; Jacques Philippe
Journal:  J Biol Chem       Date:  2010-06-30       Impact factor: 5.157

10.  Genetic analysis of the Caenorhabditis elegans pax-6 locus: roles of paired domain-containing and nonpaired domain-containing isoforms.

Authors:  Hediye Nese Cinar; Andrew D Chisholm
Journal:  Genetics       Date:  2004-11       Impact factor: 4.562
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