Literature DB >> 9056019

Potent antifungal effects of a new derivative of partricin A in a murine model of cerebral cryptococcosis.

T Luna1, R Mazzolla, G Romanò, E Blasi.   

Abstract

A new member of the polyene family, N-dimethylaminoacetyl-partricin A 2-dimethylaminoethylamide diaspartate (SPA), was investigated and was found to be more effective than amphotericin B (i) in vivo by enhancing mouse resistance to cryptococcal meningoencephalitis and (ii) in vitro by potentiating the anticryptococcal activity of murine microglial cells.

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Year:  1997        PMID： 9056019      PMCID： PMC163777     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

Review 1.  Antifungal agents: chemotherapeutic targets and immunologic strategies.

Authors:  N H Georgopapadakou; T J Walsh
Journal:  Antimicrob Agents Chemother       Date:  1996-02       Impact factor: 5.191

Review 2.  Role of the capsule in phagocytosis of Cryptococcus neoformans.

Authors:  T R Kozel; G S Pfrommer; A S Guerlain; B A Highison; G J Highison
Journal:  Rev Infect Dis       Date:  1988 Jul-Aug

3.  Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus.

Authors:  E Blasi; R Barluzzi; V Bocchini; R Mazzolla; F Bistoni
Journal:  J Neuroimmunol       Date:  1990-05       Impact factor: 3.478

4.  Cryptococcosis in the acquired immunodeficiency syndrome.

Authors:  J A Kovacs; A A Kovacs; M Polis; W C Wright; V J Gill; C U Tuazon; E P Gelmann; H C Lane; R Longfield; G Overturf
Journal:  Ann Intern Med       Date:  1985-10       Impact factor: 25.391

5.  Anticryptococcal resistance in the mouse brain: beneficial effects of local administration of heat-inactivated yeast cells.

Authors:  E Blasi; R Mazzolla; R Barluzzi; P Mosci; F Bistoni
Journal:  Infect Immun       Date:  1994-08       Impact factor: 3.441

6.  Pattern of cytokine gene expression in brains of mice protected by picolinic acid against lethal intracerebral infection with Candida albicans.

Authors:  E Blasi; A Bartoli; R Barluzzi; R Mazzolla; F Bistoni
Journal:  J Neuroimmunol       Date:  1994-07       Impact factor: 3.478

7.  Protective effect of picolinic acid on mice intracerebrally infected with lethal doses of Candida albicans.

Authors:  E Blasi; R Mazzolla; L Pitzurra; R Barluzzi; F Bistoni
Journal:  Antimicrob Agents Chemother       Date:  1993-11       Impact factor: 5.191

8.  Encapsulation of Cryptococcus neoformans impairs antigen-specific T-cell responses.

Authors:  H L Collins; G J Bancroft
Journal:  Infect Immun       Date:  1991-11       Impact factor: 3.441

9.  Cryptococcal disease in patients with the acquired immunodeficiency syndrome. Diagnostic features and outcome of treatment.

Authors:  A Zuger; E Louie; R S Holzman; M S Simberkoff; J J Rahal
Journal:  Ann Intern Med       Date:  1986-02       Impact factor: 25.391

10.  Experimental model of intracerebral infection with Cryptococcus neoformans: roles of phagocytes and opsonization.

Authors:  E Blasi; R Barluzzi; R Mazzolla; P Mosci; F Bistoni
Journal:  Infect Immun       Date:  1992-09       Impact factor: 3.441
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  1 in total

Review 1.  SPK-843 (Aparts/Kaken).

Authors:  Noer Kasanah; Mark T Hamann
Journal:  Curr Opin Investig Drugs       Date:  2005-08
  1 in total

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