| Literature DB >> 9055856 |
R Sarid1, T Sato, R A Bohenzky, J J Russo, Y Chang.
Abstract
Kaposi's sarcoma-associated herpesvirus (KSHV) is a newly discovered herpesvirus etiologically associated with Kaposi's sarcoma (KS) and two lymphoproliferative disorders. We describe a KSHV vbcl-2 gene with homology to the proto-oncogene bcl-2. It is expressed in KS lesions and in cell lines derived from primary effusion lymphomas. Using yeast and human cells we demonstrate the ability of KSHV vBcl-2 protein to suppress Bax toxicity. We show that KSHV vBcl-2 heterodimerizes with human Bcl-2 in a yeast two-hybrid system. These results suggest that KSHV vBcl-2 plays an anti-apoptotic role in virus infected cells.Entities:
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Year: 1997 PMID： 9055856 DOI： 10.1038/nm0397-293
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440