Literature DB >> 9054936

The relationship between chromosome structure and function at a human telomeric region.

J Flint1, K Thomas, G Micklem, H Raynham, K Clark, N A Doggett, A King, D R Higgs.   

Abstract

We have sequenced a contiguous 284,495-bp segment of DNA extending from the terminal (TTAGGG)n repeats of the short arm of chromosome 16, providing a full description of the transition from telomeric through subtelomeric DNA to sequences that are unique to the chromosome. To complement and extend analysis of the primary sequence, we have characterized mRNA transcripts, patterns of DNA methylation and DNase I sensitivity. Together with previous data these studies describe in detail the structural and functional organization of a human telomeric region.

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Year:  1997        PMID： 9054936     DOI： 10.1038/ng0397-252

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  39 in total

1.  Long-range comparison of human and mouse SCL loci: localized regions of sensitivity to restriction endonucleases correspond precisely with peaks of conserved noncoding sequences.

Authors:  B Göttgens; J G Gilbert; L M Barton; D Grafham; J Rogers; D R Bentley; A R Green
Journal:  Genome Res       Date:  2001-01       Impact factor: 9.043

2.  Comparative sequence analysis of human minisatellites showing meiotic repeat instability.

Authors:  J Murray; J Buard; D L Neil; E Yeramian; K Tamaki; C Hollies; A J Jeffreys
Journal:  Genome Res       Date:  1999-02       Impact factor: 9.043

3.  Identification of a conserved erythroid specific domain of histone acetylation across the alpha-globin gene cluster.

Authors:  E Anguita; C A Johnson; W G Wood; B M Turner; D R Higgs
Journal:  Proc Natl Acad Sci U S A       Date:  2001-10-02       Impact factor: 11.205

4.  Mapping and initial analysis of human subtelomeric sequence assemblies.

Authors:  Harold Riethman; Anthony Ambrosini; Carlos Castaneda; Jeffrey Finklestein; Xue-Lan Hu; Uma Mudunuri; Sheila Paul; Jun Wei
Journal:  Genome Res       Date:  2004-01       Impact factor: 9.043

Review 5.  The control of expression of the alpha-globin gene cluster.

Authors:  Hua-bing Zhang; De-Pei Liu; Chih-Chuan Liang
Journal:  Int J Hematol       Date:  2002-12       Impact factor: 2.490

6.  Comparative analysis of the alpha-like globin clusters in mouse, rat, and human chromosomes indicates a mechanism underlying breaks in conserved synteny.

Authors:  Cristina Tufarelli; Ross Hardison; Webb Miller; Jim Hughes; Kevin Clark; Nicki Ventress; Anna Maria Frischauf; Douglas R Higgs
Journal:  Genome Res       Date:  2004-04       Impact factor: 9.043

7.  Annotation of cis-regulatory elements by identification, subclassification, and functional assessment of multispecies conserved sequences.

Authors:  Jim R Hughes; Jan-Fang Cheng; Nicki Ventress; Shyam Prabhakar; Kevin Clark; Eduardo Anguita; Marco De Gobbi; Pieter de Jong; Eddy Rubin; Douglas R Higgs
Journal:  Proc Natl Acad Sci U S A       Date:  2005-07-05       Impact factor: 11.205

8.  Increased DNA methylation at the AXIN1 gene in a monozygotic twin from a pair discordant for a caudal duplication anomaly.

Authors:  N A Oates; J van Vliet; D L Duffy; H Y Kroes; N G Martin; D I Boomsma; M Campbell; M G Coulthard; E Whitelaw; S Chong
Journal:  Am J Hum Genet       Date:  2006-05-22       Impact factor: 11.025

9.  Epigenetic analysis of the human alpha- and beta-globin gene clusters.

Authors:  Hassana Fathallah; Gregory Portnoy; George F Atweh
Journal:  Blood Cells Mol Dis       Date:  2007-10-29       Impact factor: 3.039

10.  The role of the polycomb complex in silencing alpha-globin gene expression in nonerythroid cells.

Authors:  David Garrick; Marco De Gobbi; Vasiliki Samara; Michelle Rugless; Michelle Holland; Helena Ayyub; Karen Lower; Jackie Sloane-Stanley; Nicki Gray; Christoph Koch; Ian Dunham; Douglas R Higgs
Journal:  Blood       Date:  2008-08-08       Impact factor: 22.113
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