OBJECTIVE: This 36-week multicenter double-blind placebo-controlled study was designed to assess the safety and efficacy of acarbose, administered in conjunction with diet and insulin therapy, for the treatment of patients with type I diabetes. RESEARCH DESIGN AND METHODS: Acarbose was administered using a forced titration protocol in dosages ranging from 50 to 300 mg t.i.d. RESULTS: Treatment with acarbose was associated with a mean reduction in postprandial glucose levels (60 min after the administration of a test meal) of 59 mg/dl and a mean reduction in HbA1c levels of 0.48%. There was no difference in the incidence of hypoglycemia between treatment groups. Gastrointestinal events, including flatulence, diarrhea, and abdominal pain, were reported more frequently in acarbose-treated patients than in placebo-treated patients. CONCLUSIONS:Acarbose was found to be a safe and effective agent, when used in combination with diet and insulin therapy, for the treatment of type I diabetes.
RCT Entities:
OBJECTIVE: This 36-week multicenter double-blind placebo-controlled study was designed to assess the safety and efficacy of acarbose, administered in conjunction with diet and insulin therapy, for the treatment of patients with type I diabetes. RESEARCH DESIGN AND METHODS: Acarbose was administered using a forced titration protocol in dosages ranging from 50 to 300 mg t.i.d. RESULTS: Treatment with acarbose was associated with a mean reduction in postprandial glucose levels (60 min after the administration of a test meal) of 59 mg/dl and a mean reduction in HbA1c levels of 0.48%. There was no difference in the incidence of hypoglycemia between treatment groups. Gastrointestinal events, including flatulence, diarrhea, and abdominal pain, were reported more frequently in acarbose-treated patients than in placebo-treated patients. CONCLUSIONS:Acarbose was found to be a safe and effective agent, when used in combination with diet and insulin therapy, for the treatment of type I diabetes.
Authors: Dieter Neuser; Alice Benson; Andreas Brückner; Ronald B Goldberg; Byron J Hoogwerf; Dieter Petzinna Journal: Clin Drug Investig Date: 2005 Impact factor: 2.859
Authors: Nor Adlin Yusoff; Mariam Ahmad; Bassel Al-Hindi; Tri Widyawati; Mun Fei Yam; Roziahanim Mahmud; Khairul Niza Abdul Razak; Mohd Zaini Asmawi Journal: Nutrients Date: 2015-08-20 Impact factor: 5.717