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Literature DB >> 9050874

Incomplete endoplasmic reticulum (ER) retention in immature thymocytes as revealed by surface expression of "ER-resident" molecular chaperones.

D L Wiest¹, A Bhandoola, J Punt, G Kreibich, D McKean, A Singer.

Abstract

The folding and assembly of nascent proteins in the endoplasmic reticulum (ER) is assisted by molecular chaperones that are themselves retained within the ER. We now report that a number of different ER proteins, including molecular chaperones, are selectively expressed on the surface of immature thymocytes, but their surface expression is extinguished upon further differentiation. Escape from the ER is only possible for newly synthesized ER proteins before they become permanently retained. Thus, the cellular process of ER retention is incomplete in immature thymocytes and provides an explanation for surface expression of partial receptor complexes that transduce differentiative signals during thymic development.

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Year: 1997 PMID： 9050874 PMCID： PMC20012 DOI： 10.1073/pnas.94.5.1884

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

51 in total

1. ERD2, a yeast gene required for the receptor-mediated retrieval of luminal ER proteins from the secretory pathway.

Authors: J C Semenza; K G Hardwick; N Dean; H R Pelham
Journal: Cell Date: 1990-06-29 Impact factor: 41.582

2. Structure and biosynthesis of the signal-sequence receptor.

Authors: S Prehn; J Herz; E Hartmann; T V Kurzchalia; R Frank; K Roemisch; B Dobberstein; T A Rapoport
Journal: Eur J Biochem Date: 1990-03-10

3. The ERD2 gene determines the specificity of the luminal ER protein retention system.

Authors: M J Lewis; D J Sweet; H R Pelham
Journal: Cell Date: 1990-06-29 Impact factor: 41.582

4. Identification of a monoclonal antibody specific for a murine T3 polypeptide.

Authors: O Leo; M Foo; D H Sachs; L E Samelson; J A Bluestone
Journal: Proc Natl Acad Sci U S A Date: 1987-03 Impact factor: 11.205

5. Immunoglobulin heavy chain binding protein.

Authors: I G Haas; M Wabl
Journal: Nature Date: 1983 Nov 24-30 Impact factor: 49.962

6. Identification of a consensus motif for retention of transmembrane proteins in the endoplasmic reticulum.

Authors: M R Jackson; T Nilsson; P A Peterson
Journal: EMBO J Date: 1990-10 Impact factor: 11.598

7. ERD1, a yeast gene required for the retention of luminal endoplasmic reticulum proteins, affects glycoprotein processing in the Golgi apparatus.

Authors: K G Hardwick; M J Lewis; J Semenza; N Dean; H R Pelham
Journal: EMBO J Date: 1990-03 Impact factor: 11.598

8. Evidence that luminal ER proteins are sorted from secreted proteins in a post-ER compartment.

Authors: H R Pelham
Journal: EMBO J Date: 1988-04 Impact factor: 11.598

9. Proteins of rough microsomal membranes related to ribosome binding. I. Identification of ribophorins I and II, membrane proteins characteristics of rough microsomes.

Authors: G Kreibich; B L Ulrich; D D Sabatini
Journal: J Cell Biol Date: 1978-05 Impact factor: 10.539

10. Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER.

Authors: J Lippincott-Schwartz; L C Yuan; J S Bonifacino; R D Klausner
Journal: Cell Date: 1989-03-10 Impact factor: 41.582

28 in total

Incomplete endoplasmic reticulum (ER) retention in immature thymocytes as revealed by surface expression of "ER-resident" molecular chaperones.

1. ERD2, a yeast gene required for the receptor-mediated retrieval of luminal ER proteins from the secretory pathway.

2. Structure and biosynthesis of the signal-sequence receptor.

3. The ERD2 gene determines the specificity of the luminal ER protein retention system.

4. Identification of a monoclonal antibody specific for a murine T3 polypeptide.

5. Immunoglobulin heavy chain binding protein.

6. Identification of a consensus motif for retention of transmembrane proteins in the endoplasmic reticulum.

7. ERD1, a yeast gene required for the retention of luminal endoplasmic reticulum proteins, affects glycoprotein processing in the Golgi apparatus.

8. Evidence that luminal ER proteins are sorted from secreted proteins in a post-ER compartment.

9. Proteins of rough microsomal membranes related to ribosome binding. I. Identification of ribophorins I and II, membrane proteins characteristics of rough microsomes.

10. Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER.

1. The KDEL receptor mediates a retrieval mechanism that contributes to quality control at the endoplasmic reticulum.

2. Bacterial stimulation upregulates the surface expression of the stress protein gp96 on B cells in the frog Xenopus.

3. Expression and distribution of grp-78/bip in mineralizing tissues and mesenchymal cells.

4. Localization of GRP78 to mitochondria under the unfolded protein response.

5. Stress chaperone GRP-78 functions in mineralized matrix formation.

6. Transthyretin binds to glucose-regulated proteins and is subjected to endocytosis by the pancreatic β-cell.

Review 7. Multifunctional ECM proteins in bone and teeth.

8. Cell-surface HSP70 associates with thrombomodulin in endothelial cells.

9. Cell-surface processing of the metalloprotease pro-ADAMTS9 is influenced by the chaperone GRP94/gp96.

10. Identification of phosphorylation-dependent binding partners of aquaporin-2 using protein mass spectrometry.