Literature DB >> 9050376

Mechanisms of lymphocyte killing by HIV.

C R Casella1, T H Finkel.   

Abstract

One of the remaining mysteries of HIV infection is what causes the destruction of the CD4+ T cells. Several reports in the past year have linked viral load to disease progression, strengthening the conclusion that the virus is responsible for CD4+ T-cell depletion. We discuss several possible mechanisms of T-cell death, including the killing of uninfected CD4+ T cells. We also discuss the possibility that the virus protects the cell it infects at least until viral replication can be completed.

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Year:  1997        PMID： 9050376     DOI： 10.1097/00062752-199704010-00005

Source DB:  PubMed          Journal:  Curr Opin Hematol        ISSN： 1065-6251            Impact factor:   3.284


  9 in total

1.  Human immunodeficiency virus type 1 induces apoptosis in CD4(+) but not in CD8(+) T cells in ex vivo-infected human lymphoid tissue.

Authors:  J C Grivel; N Malkevitch; L Margolis
Journal:  J Virol       Date:  2000-09       Impact factor: 5.103

2.  Ligation of CD8 leads to apoptosis of thymocytes that have not undergone positive selection.

Authors:  Kristie M Grebe; Raedun L Clarke; Terry A Potter
Journal:  Proc Natl Acad Sci U S A       Date:  2004-07-01       Impact factor: 11.205

3.  Lymphatic tissue fibrosis is associated with reduced numbers of naive CD4+ T cells in human immunodeficiency virus type 1 infection.

Authors:  Timothy W Schacker; Jason M Brenchley; Gregory J Beilman; Cavan Reilly; Stefan E Pambuccian; Jodie Taylor; David Skarda; Matthew Larson; Daniel C Douek; Ashley T Haase
Journal:  Clin Vaccine Immunol       Date:  2006-05

4.  Human immunodeficiency virus type 1 strains R5 and X4 induce different pathogenic effects in hu-PBL-SCID mice, depending on the state of activation/differentiation of human target cells at the time of primary infection.

Authors:  S Fais; C Lapenta; S M Santini; M Spada; S Parlato; M Logozzi; P Rizza; F Belardelli
Journal:  J Virol       Date:  1999-08       Impact factor: 5.103

5.  Presence of host ICAM-1 in laboratory and clinical strains of human immunodeficiency virus type 1 increases virus infectivity and CD4(+)-T-cell depletion in human lymphoid tissue, a major site of replication in vivo.

Authors:  Salim Bounou; Jacques E Leclerc; Michel J Tremblay
Journal:  J Virol       Date:  2002-02       Impact factor: 5.103

Review 6.  Chronic immune activation associated with chronic helminthic and human immunodeficiency virus infections: role of hyporesponsiveness and anergy.

Authors:  Gadi Borkow; Zvi Bentwich
Journal:  Clin Microbiol Rev       Date:  2004-10       Impact factor: 26.132

7.  Toward development and production of human T cells in swine for potential use in adoptive T cell immunotherapy.

Authors:  Brenda M Ogle; Bruce E Knudsen; Ryuta Nishitai; Kiyoshi Ogata; Jeffrey L Platt
Journal:  Tissue Eng Part A       Date:  2009-05       Impact factor: 3.845

8.  CD4(+) T-lymphocyte depletion in human lymphoid tissue ex vivo is not induced by noninfectious human immunodeficiency virus type 1 virions.

Authors:  A W Sylwester; J C Grivel; W Fitzgerald; J L Rossio; J D Lifson; L B Margolis
Journal:  J Virol       Date:  1998-11       Impact factor: 5.103

9.  Peripheral blood cytotoxic gammadelta T lymphocytes from patients with human immunodeficiency virus type 1 infection and AIDS lyse uninfected CD4+ T cells, and their cytocidal potential correlates with viral load.

Authors:  Sardar T A K Sindhu; Rasheed Ahmad; Richard Morisset; Ali Ahmad; José Menezes
Journal:  J Virol       Date:  2003-02       Impact factor: 5.103
  9 in total

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