Literature DB >> 9765486

CD4(+) T-lymphocyte depletion in human lymphoid tissue ex vivo is not induced by noninfectious human immunodeficiency virus type 1 virions.

A W Sylwester1, J C Grivel, W Fitzgerald, J L Rossio, J D Lifson, L B Margolis.   

Abstract

We tested infectious human immunodeficiency virus type 1 (HIV-1), noninfectious but conformationally authentic inactivated whole HIV-1 virions, and purified gp120 for the ability to induce depletion of CD4(+) T cells in human lymphoid tissues ex vivo. Infectious CXCR4-tropic HIV-1, but not matched inactivated virions or gp120, mediated CD4(+) T-cell depletion, consistent with mechanisms requiring productive infection.

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Year:  1998        PMID： 9765486      PMCID： PMC110358     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  30 in total

1.  Inactivation of human immunodeficiency virus type 1 infectivity with preservation of conformational and functional integrity of virion surface proteins.

Authors:  J L Rossio; M T Esser; K Suryanarayana; D K Schneider; J W Bess; G M Vasquez; T A Wiltrout; E Chertova; M K Grimes; Q Sattentau; L O Arthur; L E Henderson; J D Lifson
Journal:  J Virol       Date:  1998-10       Impact factor: 5.103

2.  Infection of human tonsil histocultures: a model for HIV pathogenesis.

Authors:  S Glushakova; B Baibakov; L B Margolis; J Zimmerberg
Journal:  Nat Med       Date:  1995-12       Impact factor: 53.440

3.  HIV type 1 Tat protein induces apoptosis and death in Jurkat cells.

Authors:  S F Purvis; J W Jacobberger; R M Sramkoski; A H Patki; M M Lederman
Journal:  AIDS Res Hum Retroviruses       Date:  1995-04       Impact factor: 2.205

Review 4.  Direct and indirect mechanisms mediating apoptosis during HIV infection: contribution to in vivo CD4 T cell depletion.

Authors:  M L Gougeon; A G Laurent-Crawford; A G Hovanessian; L Montagnier
Journal:  Semin Immunol       Date:  1993-06       Impact factor: 11.130

5.  Programmed cell death (apoptosis) and AIDS pathogenesis.

Authors:  J C Ameisen
Journal:  AIDS Res Hum Retroviruses       Date:  1994-08       Impact factor: 2.205

6.  Membrane expression of HIV envelope glycoproteins triggers apoptosis in CD4 cells.

Authors:  A G Laurent-Crawford; B Krust; Y Rivière; C Desgranges; S Muller; M P Kieny; C Dauguet; A G Hovanessian
Journal:  AIDS Res Hum Retroviruses       Date:  1993-08       Impact factor: 2.205

7.  Programmed death of T cells in HIV-1 infection.

Authors:  L Meyaard; S A Otto; R R Jonker; M J Mijnster; R P Keet; F Miedema
Journal:  Science       Date:  1992-07-10       Impact factor: 47.728

8.  Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes.

Authors:  T H Finkel; G Tudor-Williams; N K Banda; M F Cotton; T Curiel; C Monks; T W Baba; R M Ruprecht; A Kupfer
Journal:  Nat Med       Date:  1995-02       Impact factor: 53.440

9.  Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120.

Authors:  M O Westendorp; R Frank; C Ochsenbauer; K Stricker; J Dhein; H Walczak; K M Debatin; P H Krammer
Journal:  Nature       Date:  1995-06-08       Impact factor: 49.962

10.  Localization of HIV RNA in mitochondria of infected cells: potential role in cytopathogenicity.

Authors:  M Somasundaran; M L Zapp; L K Beattie; L Pang; K S Byron; G J Bassell; J L Sullivan; R H Singer
Journal:  J Cell Biol       Date:  1994-09       Impact factor: 10.539
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  6 in total

1.  Human immunodeficiency virus type 1 induces apoptosis in CD4(+) but not in CD8(+) T cells in ex vivo-infected human lymphoid tissue.

Authors:  J C Grivel; N Malkevitch; L Margolis
Journal:  J Virol       Date:  2000-09       Impact factor: 5.103

2.  Kinetics of human immunodeficiency virus type 1 decay following entry into resting CD4+ T cells.

Authors:  Yan Zhou; Haili Zhang; Janet D Siliciano; Robert F Siliciano
Journal:  J Virol       Date:  2005-02       Impact factor: 5.103

3.  Fusion-induced apoptosis contributes to thymocyte depletion by a pathogenic human immunodeficiency virus type 1 envelope in the human thymus.

Authors:  Eric G Meissner; Liguo Zhang; S Jiang; Lishan Su
Journal:  J Virol       Date:  2006-09-06       Impact factor: 5.103

4.  Inhibition of human immunodeficiency virus type 1 gp120 presentation to CD4 T cells by antibodies specific for the CD4 binding domain of gp120.

Authors:  C E Hioe; M Tuen; P C Chien; G Jones; S Ratto-Kim; P J Norris; W J Moretto; D F Nixon; M K Gorny; S Zolla-Pazner
Journal:  J Virol       Date:  2001-11       Impact factor: 5.103

5.  Noninfectious X4 but not R5 human immunodeficiency virus type 1 virions inhibit humoral immune responses in human lymphoid tissue ex vivo.

Authors:  Wendy Fitzgerald; Andrew W Sylwester; Jean-Charles Grivel; Jeffrey D Lifson; Leonid B Margolis
Journal:  J Virol       Date:  2004-07       Impact factor: 5.103

6.  Cytolysis by CCR5-using human immunodeficiency virus type 1 envelope glycoproteins is dependent on membrane fusion and can be inhibited by high levels of CD4 expression.

Authors:  Jason A LaBonte; Navid Madani; Joseph Sodroski
Journal:  J Virol       Date:  2003-06       Impact factor: 5.103
  6 in total

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