Literature DB >> 904684

Structure of a dinucleoside phosphate--drug complex as model for nucleic acid--drug interaction.

S Neidle, A Achari, G L Taylor, H M Berman, H L Carrell, J P Glusker, W C Stallings.   

Abstract

The crystal structure of a 3:2 complex of the frameshift mutagen proflavine with the dinucleoside phosphate cytidylyl-3'5'-guanosine has been determined. The complex has one drug molecule intercalated between Watson--Crick base pairs of the nucleotide duplex. The other two proflavine molecules are bound to the exterior of the miniature double helix. The orientation of the base pairs in this miniature double helix has aspects similar to that found in RNA 11.

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Year:  1977        PMID： 904684     DOI： 10.1038/269304a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  11 in total

1.  A suggestion for naming faces of ring compounds.

Authors:  I A Rose; K R Hanson; K D Wilkinson; M J Wimmer
Journal:  Proc Natl Acad Sci U S A       Date:  1980-05       Impact factor: 11.205

2.  Drug-nucleic acid interactions: conformational flexibility at the intercalation site.

Authors:  H M Berman; S Neidle; R K Stodola
Journal:  Proc Natl Acad Sci U S A       Date:  1978-02       Impact factor: 11.205

3.  Evidence for an increase of DNA contour length at low ionic strength.

Authors:  K Geller; K E Reinert
Journal:  Nucleic Acids Res       Date:  1980-06-25       Impact factor: 16.971

4.  Spectroscopic properties of ethidium monoazide: a fluorescent photoaffinity label for nucleic acids.

Authors:  P H Bolton; D R Kearns
Journal:  Nucleic Acids Res       Date:  1978-12       Impact factor: 16.971

5.  Atomic resolution analysis of a 2:1 complex of CpG and acridine orange.

Authors:  A H Wang; G J Quigley; A Rich
Journal:  Nucleic Acids Res       Date:  1979-08-24       Impact factor: 16.971

6.  A 1:2 crystalline complex of ApA:proflavine: a model for binding to single-stranded regions in RNA.

Authors:  S Neidle; G Taylor; M Sanderson
Journal:  Nucleic Acids Res       Date:  1978-11       Impact factor: 16.971

7.  Molecular mechanical simulations on double intercalation of 9-amino acridine into d(CGCGCGC) X d(GCGCGCG): analysis of the physical basis for the neighbor-exclusion principle.

Authors:  S N Rao; P A Kollman
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

8.  The structure of drug-deoxydinucleoside phosphate complex; generalized conformational behavior of intercalation complexes with RNA and DNA fragments.

Authors:  H S Shieh; H M Berman; M Dabrow; S Neidle
Journal:  Nucleic Acids Res       Date:  1980-01-11       Impact factor: 16.971

9.  Sugar pucker geometries at the intercalation site of propidium diiodide into miniature RNA and DNA duplexes in solution.

Authors:  D J Patel; C Shen
Journal:  Proc Natl Acad Sci U S A       Date:  1978-06       Impact factor: 11.205

10.  Molecular structure of an anticancer drug-DNA complex: daunomycin plus d(CpGpTpApCpG).

Authors:  G J Quigley; A H Wang; G Ughetto; G van der Marel; J H van Boom; A Rich
Journal:  Proc Natl Acad Sci U S A       Date:  1980-12       Impact factor: 11.205
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