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Literature DB >> 904622

Studies of interaction of immune RNA with normal spleen cells.

Abstract

Normal mouse spleen cells incorporate in vitro radioactively labeled immune RNA. At saturation, 10(6) cells incorporate about 6 X 10(16) daltons of this RNA. Immune RNA is incorporated in two times greater amounts than control RNA. Maximum incorporation is observed in the first few minutes of incubation. Immune RNA incorporated by spleen cells is present both in cytoplasm and nuclei. Protamine sulphate has stimulatory effect on immune RNA incorporation. Actinomycin D does not affect incorporation of immune RNA.

Entities: Chemical Species

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Year: 1977 PMID： 904622 DOI： 10.1007/bf01743431

Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396

12 in total

1. Induction of antibody synthesis in vitro by immunogenic RNA.

Authors: R Slomski; A Horst
Journal: Ann Med Sect Pol Acad Sci Date: 1975

2. Induction of antibody synthesis by purified immunogenic RNA in vitro.

Authors: L J Duke; C Miller; S Harshman
Journal: Nat New Biol Date: 1972-02-09

3. In vitro conversion of normal mouse lymphocytes by plasmacytoma RNA to express idiotypic specificities on their surface characteristic of the plasmacytoma immunoglobulin.

Authors: D Giacomoni; V Yakulis; S R Wang; A Cooke; S Dray; P Heller
Journal: Cell Immunol Date: 1974-03-30 Impact factor: 4.868

8. Conversion of non-immune spleen cells by ribonucleic acid of lymphoid cells from an immunized rabbit to produce gammaM antibody of foreign light chain allotype.

Authors: C Bell; S Dray
Journal: J Immunol Date: 1969-12 Impact factor: 5.422

Studies of interaction of immune RNA with normal spleen cells.

1. Induction of antibody synthesis in vitro by immunogenic RNA.

2. Induction of antibody synthesis by purified immunogenic RNA in vitro.

3. In vitro conversion of normal mouse lymphocytes by plasmacytoma RNA to express idiotypic specificities on their surface characteristic of the plasmacytoma immunoglobulin.

4. Conversion of non-immune cells into antibody-forming cells by RNA.

5. Changes in haemolytic plaque size during the primary immune response of mice.

6. Immunogenicity of mouse spleen RNA.

7. Physical and chemical characterization of RNA incorporated by rabbit spleen cells.

8. Conversion of non-immune spleen cells by ribonucleic acid of lymphoid cells from an immunized rabbit to produce gammaM antibody of foreign light chain allotype.

9. Gene regulation for higher cells: a theory.

10. Cytoplasmic RNA in the mouse spleen at the peak of primary immune response.

1. Uptake of immune RNA by normal mouse spleen cells.