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Literature DB >> 9045609

Oxidative thymine dimer repair in the DNA helix.

P J Dandliker¹, R E Holmlin, J K Barton.

Abstract

The metallointercalator Rh(phi)2DMB3+ (phi, 9,10-phenanthrenequinone diimine; DMB, 4,4'-dimethyl-2,2'-bipyridine) catalyzed the repair of a thymine dimer incorporated site-specifically in a 16-base pair DNA duplex by means of visible light. This repair could be accomplished with rhodium noncovalently bound to the duplex and at long range (16 to 26 angstroms), with the rhodium intercalator tethered to either end of the duplex assembly. This long-range repair was mediated by the DNA helix. Repair efficiency did not decrease with increasing distance between intercalated rhodium and the thymine dimer, but it diminished with disruption of the intervening pi-stack.

Entities: Chemical

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Year: 1997 PMID： 9045609 DOI： 10.1126/science.275.5305.1465

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

21 in total

1. Long-range charge hopping in DNA.

Authors: M Bixon; B Giese; S Wessely; T Langenbacher; M E Michel-Beyerle; J Jortner
Journal: Proc Natl Acad Sci U S A Date: 1999-10-12 Impact factor: 11.205

2. Femtosecond dynamics of DNA-mediated electron transfer.

Authors: C Wan; T Fiebig; S O Kelley; C R Treadway; J K Barton; A H Zewail
Journal: Proc Natl Acad Sci U S A Date: 1999-05-25 Impact factor: 11.205

3. Efficient cycloreversion of cis,syn-thymine photodimer by a Zn2+ -1,4,7,10-tetraazacyclododecane complex bearing a lumiflavin and tryptophan by chemical reduction and photoreduction of a lumiflavin unit.

Authors: Yasuyuki Yamada; Shin Aoki
Journal: J Biol Inorg Chem Date: 2006-08-30 Impact factor: 3.358

Oxidative thymine dimer repair in the DNA helix.

1. Long-range charge hopping in DNA.

2. Femtosecond dynamics of DNA-mediated electron transfer.

3. Efficient cycloreversion of cis,syn-thymine photodimer by a Zn2+ -1,4,7,10-tetraazacyclododecane complex bearing a lumiflavin and tryptophan by chemical reduction and photoreduction of a lumiflavin unit.

4. Long-range oxidative damage to cytosines in duplex DNA.

5. Origin of the heterogeneous distribution of the yield of guanyl radical in UV laser photolyzed DNA.

6. Complementary base-pair-facilitated electron tunneling for electrically pinpointing complementary nucleobases.

7. A role for DNA-mediated charge transport in regulating p53: Oxidation of the DNA-bound protein from a distance.

8. Conductivity of a single DNA duplex bridging a carbon nanotube gap.

9. Charge transfer and transport in DNA.

10. Detection of thymine [2+2] photodimer repair in DNA: selective reaction of KMnO4.