Literature DB >> 9040041

Increased expression of cardiac phosphatases in patients with end-stage heart failure.

J Neumann1, T Eschenhagen, L R Jones, B Linck, W Schmitz, H Scholz, N Zimmermann.   

Abstract

Type 1 phosphatase activity was increased in membrane vesicles from failing human ventricles compared with non-failing controls. Likewise, expression of the mRNA encoding for type 1 phosphatase was enhanced by 37%. The present study provides evidence that alterations of phosphatase activity coincide with end-stage heart failure. Thus, enhanced activity of phosphatases may be causally related to heart failure and/or may aggravate the well known decreased cardiac responsiveness to positive inotropic agents in end-stage heart failure.

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Year:  1997        PMID： 9040041     DOI： 10.1006/jmcc.1996.0271

Source DB:  PubMed          Journal:  J Mol Cell Cardiol        ISSN： 0022-2828            Impact factor:   5.000


  82 in total

Review 1.  Transcriptional regulation by cAMP in the heart.

Authors:  F U Müller; J Neumann; W Schmitz
Journal:  Mol Cell Biochem       Date:  2000-09       Impact factor: 3.396

2.  Functional properties of the rat phosphatase 1alpha promoter.

Authors:  B Linck; P Boknik; J Knapp; K Kikuchi; H Lüss; F U Müller; K Nomoto; J Neumann; W Schmitz
Journal:  Mol Cell Biochem       Date:  2001-07       Impact factor: 3.396

3.  Type 1 phosphatase, a negative regulator of cardiac function.

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Journal:  Mol Cell Biol       Date:  2002-06       Impact factor: 4.272

Review 4.  Integration of pathways that signal cardiac growth with modulation of myofilament activity.

Authors:  R John Solaro; David M Montgomery; Lynn Wang; Eileen M Burkart; Yunbo Ke; Susan Vahebi; Peter Buttrick
Journal:  J Nucl Cardiol       Date:  2002 Sep-Oct       Impact factor: 5.952

5.  Protein phosphatases decrease sarcoplasmic reticulum calcium content by stimulating calcium release in cardiac myocytes.

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Journal:  J Physiol       Date:  2003-08-01       Impact factor: 5.182

Review 6.  Myofibrillar remodeling in cardiac hypertrophy, heart failure and cardiomyopathies.

Authors:  Jarmila Machackova; Judit Barta; Naranjan S Dhalla
Journal:  Can J Cardiol       Date:  2006-09       Impact factor: 5.223

Review 7.  Altered intracellular Ca2+ handling in heart failure.

Authors:  Masafumi Yano; Yasuhiro Ikeda; Masunori Matsuzaki
Journal:  J Clin Invest       Date:  2005-03       Impact factor: 14.808

Review 8.  Remodeling of excitation-contraction coupling in the heart: inhibition of sarcoplasmic reticulum Ca(2+) leak as a novel therapeutic approach.

Authors:  Stefan Neef; Lars S Maier
Journal:  Curr Heart Fail Rep       Date:  2007-03

Review 9.  Regulating the regulator: Insights into the cardiac protein phosphatase 1 interactome.

Authors:  David Y Chiang; Albert J R Heck; Dobromir Dobrev; Xander H T Wehrens
Journal:  J Mol Cell Cardiol       Date:  2016-09-20       Impact factor: 5.000

10.  Beta-adrenergic adaptation in paediatric idiopathic dilated cardiomyopathy.

Authors:  Shelley D Miyamoto; Brian L Stauffer; Stephanie Nakano; Rebecca Sobus; Karin Nunley; Penny Nelson; Carmen C Sucharov
Journal:  Eur Heart J       Date:  2012-07-26       Impact factor: 29.983
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