Literature DB >> 11108131

Transcriptional regulation by cAMP in the heart.

F U Müller1, J Neumann, W Schmitz.   

Abstract

Stimulation of the cAMP-dependent signalling pathway by beta-adrenergic catecholamines is an important physiological mechanism to increase contractile force in the heart. In addition to this, long-term beta-adrenergic stimulation by elevated catecholamines also influences the expressional control of functionally relevant cardiac regulatory proteins in human heart failure. The regulation of transcription by the cAMP-response element (CRE) is an important mechanism for a cAMP-mediated control of gene expression involved e.g. in spermiogenesis and memory/learning processes. This article discusses recent data leading to the hypothesis that this mechanism also contributes to altered gene regulation in heart failure.

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Year:  2000        PMID： 11108131

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  85 in total

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Journal:  Biochemistry       Date:  1991-01-08       Impact factor: 3.162

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Journal:  Mol Pharmacol       Date:  1989-03       Impact factor: 4.436

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5.  Functional analysis of the human endothelial nitric oxide synthase promoter. Sp1 and GATA factors are necessary for basal transcription in endothelial cells.

Authors:  R Zhang; W Min; W C Sessa
Journal:  J Biol Chem       Date:  1995-06-23       Impact factor: 5.157

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Journal:  Eur J Biochem       Date:  1991-03-28

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Authors:  M R Bristow; R Ginsburg; W Minobe; R S Cubicciotti; W S Sageman; K Lurie; M E Billingham; D C Harrison; E B Stinson
Journal:  N Engl J Med       Date:  1982-07-22       Impact factor: 91.245

8.  The transcription of a mammalian voltage-gated potassium channel is regulated by cAMP in a cell-specific manner.

Authors:  Y Mori; H Matsubara; E Folco; A Siegel; G Koren
Journal:  J Biol Chem       Date:  1993-12-15       Impact factor: 5.157

9.  Messenger RNA expression and immunological quantification of phospholamban and SR-Ca(2+)-ATPase in failing and nonfailing human hearts.

Authors:  B Linck; P Bokník; T Eschenhagen; F U Müller; J Neumann; M Nose; L R Jones; W Schmitz; H Scholz
Journal:  Cardiovasc Res       Date:  1996-04       Impact factor: 10.787

10.  In vivo isoproterenol treatment leads to downregulation of the mRNA encoding the cAMP response element binding protein in the rat heart.

Authors:  F U Müller; P Bokník; A Horst; J Knapp; B Linck; W Schmitz; U Vahlensieck; A Walter
Journal:  Biochem Biophys Res Commun       Date:  1995-10-24       Impact factor: 3.575
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  11 in total

Review 1.  The L-type calcium channel in the heart: the beat goes on.

Authors:  Ilona Bodi; Gabor Mikala; Sheryl E Koch; Shahab A Akhter; Arnold Schwartz
Journal:  J Clin Invest       Date:  2005-12       Impact factor: 14.808

2.  Binding of FUN14 Domain Containing 1 With Inositol 1,4,5-Trisphosphate Receptor in Mitochondria-Associated Endoplasmic Reticulum Membranes Maintains Mitochondrial Dynamics and Function in Hearts in Vivo.

Authors:  Shengnan Wu; Qiulun Lu; Qilong Wang; Ye Ding; Zejun Ma; Xiaoxiang Mao; Kai Huang; Zhonglin Xie; Ming-Hui Zou
Journal:  Circulation       Date:  2017-09-23       Impact factor: 29.690

3.  Differential role of PKA catalytic subunits in mediating phenotypes caused by knockout of the Carney complex gene Prkar1a.

Authors:  Zhirong Yin; Daphne R Pringle; Georgette N Jones; Kimberly M Kelly; Lawrence S Kirschner
Journal:  Mol Endocrinol       Date:  2011-08-18

4.  Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes.

Authors:  Zeineb Haj Slimane; Ibrahim Bedioune; Patrick Lechêne; Audrey Varin; Florence Lefebvre; Philippe Mateo; Valérie Domergue-Dupont; Matthias Dewenter; Wito Richter; Marco Conti; Ali El-Armouche; Jin Zhang; Rodolphe Fischmeister; Grégoire Vandecasteele
Journal:  Cardiovasc Res       Date:  2014-02-18       Impact factor: 10.787

5.  Cyclic mechanical strain causes cAMP-response element binding protein activation by different pathways in cardiac fibroblasts.

Authors:  Britta Husse; Gerrit Isenberg
Journal:  Heart Int       Date:  2010-06-23

Review 6.  Cardiac hypertrophy induced by sustained beta-adrenoreceptor activation: pathophysiological aspects.

Authors:  Oleg E Osadchii
Journal:  Heart Fail Rev       Date:  2007-03-27       Impact factor: 4.654

7.  Homozygous CREM-IbΔC-X Overexpressing Mice Are a Reliable and Effective Disease Model for Atrial Fibrillation.

Authors:  Frank T Stümpel; Juliane Stein; Kirsten Himmler; Beatrix Scholz; Matthias D Seidl; Boris V Skryabin; Frank U Müller
Journal:  Front Pharmacol       Date:  2018-07-05       Impact factor: 5.810

8.  Identification of Upstream Transcriptional Regulators of Ischemic Cardiomyopathy Using Cardiac RNA-Seq Meta-Analysis.

Authors:  Ahmad Alimadadi; Sachin Aryal; Ishan Manandhar; Bina Joe; Xi Cheng
Journal:  Int J Mol Sci       Date:  2020-05-14       Impact factor: 5.923

9.  Structural, Pro-Inflammatory and Calcium Handling Remodeling Underlies Spontaneous Onset of Paroxysmal Atrial Fibrillation in JDP2-Overexpressing Mice.

Authors:  Mariana S Parahuleva; Jens Kockskämper; Jacqueline Heger; Wolfram Grimm; Anna Scherer; Sarah Bühler; Julian Kreutz; Rainer Schulz; Gerhild Euler
Journal:  Int J Mol Sci       Date:  2020-11-30       Impact factor: 5.923

10.  Effects of carvedilol treatment on cardiac cAMP response element binding protein expression and phosphorylation in acute coxsackievirus B3-induced myocarditis.

Authors:  Ge Li-Sha; Chen Yi-He; Zhou Na-Dan; Zhang Teng; Li Yue-Chun
Journal:  BMC Cardiovasc Disord       Date:  2013-11-14       Impact factor: 2.298
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